1NSB
THE 2.2 ANGSTROMS RESOLUTION CRYSTAL STRUCTURE OF INFLUENZA B NEURAMINIDASE AND ITS COMPLEX WITH SIALIC ACID
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0046761 | biological_process | viral budding from plasma membrane |
| A | 0055036 | cellular_component | virion membrane |
| B | 0004308 | molecular_function | exo-alpha-sialidase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0046761 | biological_process | viral budding from plasma membrane |
| B | 0055036 | cellular_component | virion membrane |
Functional Information from PDB Data
| site_id | CHA |
| Number of Residues | 5 |
| Details | HIGH-AFFINITY CALCIUM-BINDING SITES |
| Chain | Residue |
| A | ASP292 |
| A | THR296 |
| A | ASP323 |
| A | GLY343 |
| A | GLY345 |
| site_id | CHB |
| Number of Residues | 5 |
| Details | HIGH-AFFINITY CALCIUM-BINDING SITES |
| Chain | Residue |
| B | ASP292 |
| B | THR296 |
| B | ASP323 |
| B | GLY343 |
| B | GLY345 |
| site_id | CLA |
| Number of Residues | 1 |
| Details | LOW-AFFINITY CALCIUM-BINDING SITES |
| Chain | Residue |
| A | GLU167 |
| site_id | CLB |
| Number of Residues | 1 |
| Details | LOW-AFFINITY CALCIUM-BINDING SITES |
| Chain | Residue |
| B | GLU167 |
| site_id | SIA |
| Number of Residues | 9 |
| Details | ACTIVE SITE IN CHAINS A |
| Chain | Residue |
| A | TRP176 |
| A | ILE220 |
| A | ARG222 |
| A | GLU274 |
| A | ARG291 |
| A | ASP323 |
| A | ARG115 |
| A | ASP148 |
| A | ARG149 |
| site_id | SIB |
| Number of Residues | 9 |
| Details | ACTIVE SITE IN CHAINS B |
| Chain | Residue |
| B | ARG115 |
| B | ASP148 |
| B | ARG149 |
| B | TRP176 |
| B | ILE220 |
| B | ARG222 |
| B | GLU274 |
| B | ARG291 |
| B | ASP323 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 754 |
| Details | Region: {"description":"Head of neuraminidase","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1740114","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"1740114","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1740114","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| A | ASP148 | |
| A | GLU275 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| B | ASP148 | |
| B | GLU275 |
