Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1NR4

High resolution crystal structures of thymus and activation-regulated chemokine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007267	biological_process	cell-cell signaling
A	0008009	molecular_function	chemokine activity
A	0030335	biological_process	positive regulation of cell migration
A	0048020	molecular_function	CCR chemokine receptor binding
A	0060326	biological_process	cell chemotaxis
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0070098	biological_process	chemokine-mediated signaling pathway
B	0005102	molecular_function	signaling receptor binding
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006935	biological_process	chemotaxis
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007267	biological_process	cell-cell signaling
B	0008009	molecular_function	chemokine activity
B	0030335	biological_process	positive regulation of cell migration
B	0048020	molecular_function	CCR chemokine receptor binding
B	0060326	biological_process	cell chemotaxis
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0070098	biological_process	chemokine-mediated signaling pathway
C	0005102	molecular_function	signaling receptor binding
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006935	biological_process	chemotaxis
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0007267	biological_process	cell-cell signaling
C	0008009	molecular_function	chemokine activity
C	0030335	biological_process	positive regulation of cell migration
C	0048020	molecular_function	CCR chemokine receptor binding
C	0060326	biological_process	cell chemotaxis
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0070098	biological_process	chemokine-mediated signaling pathway
D	0005102	molecular_function	signaling receptor binding
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006935	biological_process	chemotaxis
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
D	0007267	biological_process	cell-cell signaling
D	0008009	molecular_function	chemokine activity
D	0030335	biological_process	positive regulation of cell migration
D	0048020	molecular_function	CCR chemokine receptor binding
D	0060326	biological_process	cell chemotaxis
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0070098	biological_process	chemokine-mediated signaling pathway
E	0005102	molecular_function	signaling receptor binding
E	0005125	molecular_function	cytokine activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006935	biological_process	chemotaxis
E	0006954	biological_process	inflammatory response
E	0006955	biological_process	immune response
E	0007267	biological_process	cell-cell signaling
E	0008009	molecular_function	chemokine activity
E	0030335	biological_process	positive regulation of cell migration
E	0048020	molecular_function	CCR chemokine receptor binding
E	0060326	biological_process	cell chemotaxis
E	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0070098	biological_process	chemokine-mediated signaling pathway
F	0005102	molecular_function	signaling receptor binding
F	0005125	molecular_function	cytokine activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006935	biological_process	chemotaxis
F	0006954	biological_process	inflammatory response
F	0006955	biological_process	immune response
F	0007267	biological_process	cell-cell signaling
F	0008009	molecular_function	chemokine activity
F	0030335	biological_process	positive regulation of cell migration
F	0048020	molecular_function	CCR chemokine receptor binding
F	0060326	biological_process	cell chemotaxis
F	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
F	0070098	biological_process	chemokine-mediated signaling pathway
G	0005102	molecular_function	signaling receptor binding
G	0005125	molecular_function	cytokine activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006935	biological_process	chemotaxis
G	0006954	biological_process	inflammatory response
G	0006955	biological_process	immune response
G	0007267	biological_process	cell-cell signaling
G	0008009	molecular_function	chemokine activity
G	0030335	biological_process	positive regulation of cell migration
G	0048020	molecular_function	CCR chemokine receptor binding
G	0060326	biological_process	cell chemotaxis
G	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
G	0070098	biological_process	chemokine-mediated signaling pathway
H	0005102	molecular_function	signaling receptor binding
H	0005125	molecular_function	cytokine activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0006935	biological_process	chemotaxis
H	0006954	biological_process	inflammatory response
H	0006955	biological_process	immune response
H	0007267	biological_process	cell-cell signaling
H	0008009	molecular_function	chemokine activity
H	0030335	biological_process	positive regulation of cell migration
H	0048020	molecular_function	CCR chemokine receptor binding
H	0060326	biological_process	cell chemotaxis
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0070098	biological_process	chemokine-mediated signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 9198

Chain	Residue
A	ARG2
B	SO49200
A	GLY3
A	THR4
A	ARG8
A	SER31
A	HOH9216
A	HOH9249
A	HOH9252
A	HOH9269

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 9199

Chain	Residue
A	LEU12
A	SER35
A	HOH9205
C	LEU12

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 9200

Chain	Residue
A	ARG8
A	GLU9
A	THR30
A	SER31
A	SO49198
A	HOH9252
B	ALA48
B	HOH9247

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 9201

Chain	Residue
A	ARG22
A	HOH9268
F	PRO20
F	LEU21
F	ARG22

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 9203

Chain	Residue
C	ARG8
C	GLU9
C	THR30
C	SER31
C	HOH9247
D	ARG47
D	ALA48

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 9204

Chain	Residue
A	THR4
A	ASN5
B	HOH9266
C	ARG36
C	HOH9224
C	HOH9255

Functional Information from PROSITE/UniProt

site_id	PS00472
Number of Residues	42
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLeyfkga..IplrkLktWyqtsed..Csrd.AIVFvtvqgrai.CS

Chain	Residue	Details
A	CYS10-SER51

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)