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1NPC

THE STRUCTURE OF NEUTRAL PROTEASE FROM BACILLUS CEREUS AT 0.2-NM RESOLUTION

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 319
ChainResidue
AASP139
AGLU178
AASP186
AGLU188
AGLU191
AHOH346

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 320
ChainResidue
AGLU178
AASN184
AASP186
AGLU191
AHOH339
AHOH357

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 321
ChainResidue
AASP58
AASP60
AVAL62
AHOH327
AHOH377
AHOH396

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 322
ChainResidue
ATYR194
ATHR195
ALYS198
AASP201
AHOH349
AHOH380

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 323
ChainResidue
AHIS143
AHIS147
AGLU167
AHOH326

site_idCA1
Number of Residues6
Details
ChainResidue
AHOH346
AASP139
AGLU178
AASP186
AGLU188
AGLU191

site_idCA2
Number of Residues6
Details
ChainResidue
AGLU178
AASN184
AASP186
AGLU191
AHOH357
AHOH339

site_idCA3
Number of Residues6
Details
ChainResidue
AASP58
AASP60
AVAL62
AHOH327
AHOH396
AHOH377

site_idCA4
Number of Residues6
Details
ChainResidue
ATYR194
ATHR195
ALYS198
AASP201
AHOH349
AHOH380

site_idZIN
Number of Residues4
Details
ChainResidue
AHIS143
AHIS147
AGLU167
AHOH326

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHELTHAV
ChainResidueDetails
AVAL140-VAL149

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE:
ChainResidueDetails
AGLU144

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton donor
ChainResidueDetails
AHIS232

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:15299677
ChainResidueDetails
AASP58
AASP60
AASP139
AGLU178
AASP186
AGLU191
ATHR195
AASP201

site_idSWS_FT_FI4
Number of Residues5
DetailsBINDING:
ChainResidueDetails
AVAL62
AASN184
AGLU188
ATYR194
ALYS198

site_idSWS_FT_FI5
Number of Residues3
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:15299677
ChainResidueDetails
AHIS143
AHIS147
AGLU167

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1tlp
ChainResidueDetails
AGLU144
AHIS232

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PDB entries from 2024-11-06

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