1NLN

CRYSTAL STRUCTURE OF HUMAN ADENOVIRUS 2 PROTEINASE WITH ITS 11 AMINO ACID COFACTOR AT 1.6 ANGSTROM RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0042025	cellular_component	host cell nucleus
A	0044423	cellular_component	virion component

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY A 600

Chain	Residue
A	THR146
A	MET157
A	GLN162
A	ARG180
A	HIS181
A	HOH1017

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04059","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8617222","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"HAMAP-Rule","id":"MF_04059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	10
Details	Peptide: {"description":"Protease cofactor","featureId":"PRO_0000036545"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	10
Details	Region: {"description":"Binds to importin alpha/beta, involved in hexon nuclear import","evidences":[{"source":"HAMAP-Rule","id":"MF_04048","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"HAMAP-Rule","id":"MF_04048","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 12758141, 8617222, 7931163

Chain	Residue	Details
A	HIS54
A	CYS122
A	GLU71
A	GLN115

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 679

Chain	Residue	Details
A	HIS54	proton acceptor, proton donor
A	GLU71	electrostatic stabiliser
A	GLN115	electrostatic stabiliser
A	CYS122	nucleofuge, nucleophile, proton acceptor, proton donor

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