1NFI
I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PROSITE/UniProt
| site_id | PS01204 |
| Number of Residues | 7 |
| Details | REL_1 NF-kappa-B/Rel/dorsal domain signature. FRYkCEG |
| Chain | Residue | Details |
| A | PHE34-GLY40 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: (3S)-3-hydroxyasparagine; by HIF1AN; partial => ECO:0000269|PubMed:17003112 |
| Chain | Residue | Details |
| E | ASN210 | |
| E | ASN244 | |
| F | ASN210 | |
| F | ASN244 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS326 | |
| C | SER75 | |
| D | LYS326 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; by PCAF and EP300; alternate => ECO:0000269|PubMed:12419806 |
| Chain | Residue | Details |
| A | LYS122 | |
| A | LYS123 | |
| C | LYS122 | |
| C | LYS123 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:12456660 |
| Chain | Residue | Details |
| A | LYS218 | |
| A | LYS221 | |
| C | LYS218 | |
| C | LYS221 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:14690596 |
| Chain | Residue | Details |
| A | THR254 | |
| C | THR254 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:12628924 |
| Chain | Residue | Details |
| A | SER276 | |
| C | SER276 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000305|PubMed:15516339 |
| Chain | Residue | Details |
| A | SER281 | |
| C | SER281 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; by SETD6; alternate => ECO:0000250|UniProtKB:Q04207 |
| Chain | Residue | Details |
| A | LYS310 | |
| C | LYS310 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKC/PRKCZ => ECO:0000250|UniProtKB:Q04207 |
| Chain | Residue | Details |
| A | SER311 | |
| C | SER311 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3) => ECO:0000269|PubMed:22649547 |
| Chain | Residue | Details |
| A | LYS37 | |
| C | LYS37 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3); alternate |
| Chain | Residue | Details |
| A | LYS122 | |
| A | LYS123 | |
| C | LYS122 | |
| C | LYS123 |
