1NDF
Carnitine Acetyltransferase in Complex with Carnitine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003997 | molecular_function | acyl-CoA oxidase activity |
| A | 0004092 | molecular_function | carnitine O-acetyltransferase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0008458 | molecular_function | carnitine O-octanoyltransferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0019254 | biological_process | carnitine metabolic process, CoA-linked |
| A | 0033540 | biological_process | fatty acid beta-oxidation using acyl-CoA oxidase |
| A | 0046459 | biological_process | short-chain fatty acid metabolic process |
| A | 0051791 | biological_process | medium-chain fatty acid metabolic process |
| B | 0003997 | molecular_function | acyl-CoA oxidase activity |
| B | 0004092 | molecular_function | carnitine O-acetyltransferase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0008458 | molecular_function | carnitine O-octanoyltransferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0019254 | biological_process | carnitine metabolic process, CoA-linked |
| B | 0033540 | biological_process | fatty acid beta-oxidation using acyl-CoA oxidase |
| B | 0046459 | biological_process | short-chain fatty acid metabolic process |
| B | 0051791 | biological_process | medium-chain fatty acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 152 A 5001 |
| Chain | Residue |
| A | TRP102 |
| A | HOH5044 |
| A | HIS343 |
| A | GLU347 |
| A | TYR452 |
| A | SER454 |
| A | THR465 |
| A | SER552 |
| A | PHE566 |
| A | HOH5025 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 152 B 6001 |
| Chain | Residue |
| B | TRP102 |
| B | HIS343 |
| B | GLU347 |
| B | TYR452 |
| B | SER454 |
| B | THR465 |
| B | SER552 |
| B | PHE566 |
| B | HOH6007 |
| B | HOH6261 |
Functional Information from PROSITE/UniProt
| site_id | PS00439 |
| Number of Residues | 16 |
| Details | ACYLTRANSF_C_1 Acyltransferases ChoActase / COT / CPT family signature 1. LPrLPVPpLqQSLdyY |
| Chain | Residue | Details |
| A | LEU35-TYR50 |
| site_id | PS00440 |
| Number of Residues | 28 |
| Details | ACYLTRANSF_C_2 Acyltransferases ChoActase / COT / CPT family signature 2. RWfDKtLqFIvaeDGscgmvyEHaaaEG |
| Chain | Residue | Details |
| A | ARG321-GLY348 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | HIS343 | |
| B | HIS343 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12526798, ECO:0000269|PubMed:15155726 |
| Chain | Residue | Details |
| A | LYS419 | |
| B | SER454 | |
| B | SER456 | |
| B | THR465 | |
| B | ARG504 | |
| B | GLN555 | |
| A | TYR452 | |
| A | SER454 | |
| A | SER456 | |
| A | THR465 | |
| A | ARG504 | |
| A | GLN555 | |
| B | LYS419 | |
| B | TYR452 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS423 | |
| B | LYS423 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| A | LYS93 | |
| B | LYS93 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| A | LYS261 | |
| B | LYS261 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P43155 |
| Chain | Residue | Details |
| A | LYS268 | |
| B | LYS268 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1q6x |
| Chain | Residue | Details |
| A | TYR107 | |
| A | SER554 | |
| A | PRO120 | |
| A | HIS343 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1q6x |
| Chain | Residue | Details |
| B | TYR107 | |
| B | SER554 | |
| B | PRO120 | |
| B | HIS343 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1q6x |
| Chain | Residue | Details |
| A | SER554 | |
| A | HIS343 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1q6x |
| Chain | Residue | Details |
| B | SER554 | |
| B | HIS343 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 629 |
| Chain | Residue | Details |
| A | TYR107 | steric role |
| A | PRO120 | steric role |
| A | HIS343 | hydrogen bond acceptor, proton acceptor, proton donor |
| A | SER554 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 629 |
| Chain | Residue | Details |
| B | TYR107 | steric role |
| B | PRO120 | steric role |
| B | HIS343 | hydrogen bond acceptor, proton acceptor, proton donor |
| B | SER554 | electrostatic stabiliser, hydrogen bond donor |
