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1NDA

THE STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN THE OXIDIZED AND NADPH REDUCED STATE

Functional Information from GO Data
ChainGOidnamespacecontents
A0004362molecular_functionglutathione-disulfide reductase (NADPH) activity
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006749biological_processglutathione metabolic process
A0015036molecular_functiondisulfide oxidoreductase activity
A0015042molecular_functiontrypanothione-disulfide reductase (NADPH) activity
A0016491molecular_functionoxidoreductase activity
A0016668molecular_functionoxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
A0034599biological_processcellular response to oxidative stress
A0045454biological_processcell redox homeostasis
A0050660molecular_functionflavin adenine dinucleotide binding
B0004362molecular_functionglutathione-disulfide reductase (NADPH) activity
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006749biological_processglutathione metabolic process
B0015036molecular_functiondisulfide oxidoreductase activity
B0015042molecular_functiontrypanothione-disulfide reductase (NADPH) activity
B0016491molecular_functionoxidoreductase activity
B0016668molecular_functionoxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
B0034599biological_processcellular response to oxidative stress
B0045454biological_processcell redox homeostasis
B0050660molecular_functionflavin adenine dinucleotide binding
C0004362molecular_functionglutathione-disulfide reductase (NADPH) activity
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006749biological_processglutathione metabolic process
C0015036molecular_functiondisulfide oxidoreductase activity
C0015042molecular_functiontrypanothione-disulfide reductase (NADPH) activity
C0016491molecular_functionoxidoreductase activity
C0016668molecular_functionoxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
C0034599biological_processcellular response to oxidative stress
C0045454biological_processcell redox homeostasis
C0050660molecular_functionflavin adenine dinucleotide binding
D0004362molecular_functionglutathione-disulfide reductase (NADPH) activity
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006749biological_processglutathione metabolic process
D0015036molecular_functiondisulfide oxidoreductase activity
D0015042molecular_functiontrypanothione-disulfide reductase (NADPH) activity
D0016491molecular_functionoxidoreductase activity
D0016668molecular_functionoxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
D0034599biological_processcellular response to oxidative stress
D0045454biological_processcell redox homeostasis
D0050660molecular_functionflavin adenine dinucleotide binding
Functional Information from PDB Data
site_idAC1
Number of Residues30
DetailsBINDING SITE FOR RESIDUE FAD A 500
ChainResidue
AGLY11
ATHR51
ACYS52
AVAL55
ACYS57
ALYS60
ATRP126
AGLY127
AALA159
ASER160
AGLY161
AGLY13
APHE198
AARG287
AARG290
ALEU294
AGLY325
AASP326
AMET332
ALEU333
ATHR334
APRO335
ASER14
BHIS460
AGLY15
AILE34
AASP35
ASER46
AALA47
AGLY50

site_idAC2
Number of Residues30
DetailsBINDING SITE FOR RESIDUE FAD B 500
ChainResidue
AHIS460
BGLY11
BGLY13
BSER14
BGLY15
BILE34
BASP35
BSER46
BALA47
BGLY50
BTHR51
BCYS52
BVAL55
BCYS57
BLYS60
BTRP126
BGLY127
BALA159
BSER160
BGLY161
BPHE198
BARG287
BARG290
BLEU294
BGLY325
BASP326
BMET332
BLEU333
BTHR334
BPRO335

site_idAC3
Number of Residues30
DetailsBINDING SITE FOR RESIDUE FAD C 500
ChainResidue
CGLY11
CGLY13
CSER14
CGLY15
CILE34
CASP35
CSER46
CALA47
CGLY50
CTHR51
CCYS52
CVAL55
CCYS57
CLYS60
CTRP126
CGLY127
CALA159
CSER160
CGLY161
CPHE198
CARG287
CARG290
CLEU294
CGLY325
CASP326
CMET332
CLEU333
CTHR334
CPRO335
DHIS460

site_idAC4
Number of Residues30
DetailsBINDING SITE FOR RESIDUE FAD D 500
ChainResidue
DGLY50
DTHR51
DCYS52
DVAL55
DCYS57
DLYS60
DTRP126
DGLY127
DALA159
DSER160
DGLY161
DPHE198
DARG287
DARG290
DLEU294
DGLY325
DASP326
DMET332
DLEU333
DTHR334
DPRO335
CHIS460
DGLY11
DGLY13
DSER14
DGLY15
DILE34
DASP35
DSER46
DALA47

Functional Information from PROSITE/UniProt
site_idPS00076
Number of Residues11
DetailsPYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP
ChainResidueDetails
AGLY49-PRO59

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000250
ChainResidueDetails
AHIS460
BHIS460
CHIS460
DHIS460

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AASP35
BASP35
CASP35
DASP35

218853

PDB entries from 2024-04-24

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