1NCR

The structure of Rhinovirus 16 when complexed with pleconaril, an antiviral compound

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Functional Information from GO Data

ChainGOidnamespacecontents
A0044162cellular_componenthost cell cytoplasmic vesicle membrane
A0044385cellular_componentintegral to membrane of host cell
A0016020cellular_componentmembrane
A0039618cellular_componentT=pseudo3 icosahedral viral capsid
A0005524molecular_functionATP binding
A0004197molecular_functioncysteine-type endopeptidase activity
A0005216molecular_functionion channel activity
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003968molecular_functionRNA-directed 5'-3' RNA polymerase activity
A0005198molecular_functionstructural molecule activity
A0006260biological_processDNA replication
A0075509biological_processendocytosis involved in viral entry into host cell
A0039520biological_processinduction by virus of host autophagy
A0039707biological_processpore formation by virus in membrane of host cell
A0044694biological_processpore-mediated entry of viral genome into host cell
A0039690biological_processpositive stranded viral RNA replication
A0051259biological_processprotein complex oligomerization
A0018144biological_processRNA-protein covalent cross-linking
A0039657biological_processsuppression by virus of host gene expression
A0039522biological_processsuppression by virus of host mRNA export from nucleus
A0039540biological_processsuppression by virus of host RIG-I activity
A0039611biological_processsuppression by virus of host translation initiation factor activity
A0006351biological_processtranscription, DNA-templated
A0039694biological_processviral RNA genome replication
A0019062biological_processvirion attachment to host cell
B0044162cellular_componenthost cell cytoplasmic vesicle membrane
B0044385cellular_componentintegral to membrane of host cell
B0016020cellular_componentmembrane
B0039618cellular_componentT=pseudo3 icosahedral viral capsid
B0005524molecular_functionATP binding
B0004197molecular_functioncysteine-type endopeptidase activity
B0005216molecular_functionion channel activity
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003968molecular_functionRNA-directed 5'-3' RNA polymerase activity
B0005198molecular_functionstructural molecule activity
B0006260biological_processDNA replication
B0075509biological_processendocytosis involved in viral entry into host cell
B0039520biological_processinduction by virus of host autophagy
B0039707biological_processpore formation by virus in membrane of host cell
B0044694biological_processpore-mediated entry of viral genome into host cell
B0039690biological_processpositive stranded viral RNA replication
B0051259biological_processprotein complex oligomerization
B0018144biological_processRNA-protein covalent cross-linking
B0039657biological_processsuppression by virus of host gene expression
B0039522biological_processsuppression by virus of host mRNA export from nucleus
B0039540biological_processsuppression by virus of host RIG-I activity
B0039611biological_processsuppression by virus of host translation initiation factor activity
B0006351biological_processtranscription, DNA-templated
B0039694biological_processviral RNA genome replication
B0019062biological_processvirion attachment to host cell
C0044162cellular_componenthost cell cytoplasmic vesicle membrane
C0044385cellular_componentintegral to membrane of host cell
C0016020cellular_componentmembrane
C0039618cellular_componentT=pseudo3 icosahedral viral capsid
C0005524molecular_functionATP binding
C0004197molecular_functioncysteine-type endopeptidase activity
C0005216molecular_functionion channel activity
C0003723molecular_functionRNA binding
C0003724molecular_functionRNA helicase activity
C0003968molecular_functionRNA-directed 5'-3' RNA polymerase activity
C0005198molecular_functionstructural molecule activity
C0006260biological_processDNA replication
C0075509biological_processendocytosis involved in viral entry into host cell
C0039520biological_processinduction by virus of host autophagy
C0039707biological_processpore formation by virus in membrane of host cell
C0044694biological_processpore-mediated entry of viral genome into host cell
C0039690biological_processpositive stranded viral RNA replication
C0051259biological_processprotein complex oligomerization
C0018144biological_processRNA-protein covalent cross-linking
C0039657biological_processsuppression by virus of host gene expression
C0039522biological_processsuppression by virus of host mRNA export from nucleus
C0039540biological_processsuppression by virus of host RIG-I activity
C0039611biological_processsuppression by virus of host translation initiation factor activity
C0006351biological_processtranscription, DNA-templated
C0039694biological_processviral RNA genome replication
C0019062biological_processvirion attachment to host cell
D0044162cellular_componenthost cell cytoplasmic vesicle membrane
D0044385cellular_componentintegral to membrane of host cell
D0016020cellular_componentmembrane
D0039618cellular_componentT=pseudo3 icosahedral viral capsid
D0005524molecular_functionATP binding
D0004197molecular_functioncysteine-type endopeptidase activity
D0005216molecular_functionion channel activity
D0003723molecular_functionRNA binding
D0003724molecular_functionRNA helicase activity
D0003968molecular_functionRNA-directed 5'-3' RNA polymerase activity
D0005198molecular_functionstructural molecule activity
D0006260biological_processDNA replication
D0075509biological_processendocytosis involved in viral entry into host cell
D0039520biological_processinduction by virus of host autophagy
D0039707biological_processpore formation by virus in membrane of host cell
D0044694biological_processpore-mediated entry of viral genome into host cell
D0039690biological_processpositive stranded viral RNA replication
D0051259biological_processprotein complex oligomerization
D0018144biological_processRNA-protein covalent cross-linking
D0039657biological_processsuppression by virus of host gene expression
D0039522biological_processsuppression by virus of host mRNA export from nucleus
D0039540biological_processsuppression by virus of host RIG-I activity
D0039611biological_processsuppression by virus of host translation initiation factor activity
D0006351biological_processtranscription, DNA-templated
D0039694biological_processviral RNA genome replication
D0019062biological_processvirion attachment to host cell
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC12BINDING SITE FOR RESIDUE MYR D 4000
ChainResidue
DGLY1
DASN30

AC217BINDING SITE FOR RESIDUE W11 A 7001
ChainResidue
AILE98
ALEU100
AILE122
AMET124
ATYR142
AMET143
ATYR144
AALA166
AVAL168
APHE179
ALEU181
ALEU184
ATYR190
AASN212
AMET214
ALEU217
AHOH7094

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
W11_1ncr_A_7001273-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE binding site
ChainResidueligand
AILE77W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
ATRP96W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AILE98-LEU100W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
APHE118W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
ASER120W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AILE122W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AMET124W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
ATYR142-TYR144W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AALA166-VAL168W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
APHE179W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
ALEU181W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
ALEU184W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
ATYR190-MET192W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AASN212W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AMET214W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
ALEU217W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AILE236W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AHIS238W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
CALA24W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE

MYR_1ncr_D_40005MYRISTIC ACID binding site
ChainResidueligand
DGLY1MYR: MYRISTIC ACID
DILE29-PHE32MYR: MYRISTIC ACID

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI13For picornain 2A activity (By similarity).
ChainResidueDetails
ANA*
ANA*
ANA*

SWS_FT_FI22For picornain 3C activity (Potential).
ChainResidueDetails
ANA*
ANA*

SWS_FT_FI31For picornain 3C activity (By similarity).
ChainResidueDetails
ANA*

SWS_FT_FI412Cleavage; by picornain 3C (Potential).
ChainResidueDetails
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*

SWS_FT_FI52Cleavage (Potential).
ChainResidueDetails
ANA*

SWS_FT_FI62Cleavage; by picornain 2A (Potential).
ChainResidueDetails
AVAL285

SWS_FT_FI78ATP (Potential).
ChainResidueDetails
ANA*

SWS_FT_FI83For picornain 2A activity (By similarity).
ChainResidueDetails
BNA*
BNA*
BNA*

SWS_FT_FI92For picornain 3C activity (Potential).
ChainResidueDetails
BNA*
BNA*

SWS_FT_FI101For picornain 3C activity (By similarity).
ChainResidueDetails
BNA*

SWS_FT_FI1112Cleavage; by picornain 3C (Potential).
ChainResidueDetails
BGLN261
BNA*
BNA*
BNA*
BNA*
BNA*

SWS_FT_FI122Cleavage (Potential).
ChainResidueDetails
BNA*

SWS_FT_FI132Cleavage; by picornain 2A (Potential).
ChainResidueDetails
BNA*

SWS_FT_FI148ATP (Potential).
ChainResidueDetails
BNA*

SWS_FT_FI153For picornain 2A activity (By similarity).
ChainResidueDetails
CNA*
CNA*
CNA*

SWS_FT_FI162For picornain 3C activity (Potential).
ChainResidueDetails
CNA*
CNA*

SWS_FT_FI171For picornain 3C activity (By similarity).
ChainResidueDetails
CNA*

SWS_FT_FI1812Cleavage; by picornain 3C (Potential).
ChainResidueDetails
CNA*
CNA*
CNA*
CNA*
CNA*
CNA*

SWS_FT_FI192Cleavage (Potential).
ChainResidueDetails
CNA*

SWS_FT_FI202Cleavage; by picornain 2A (Potential).
ChainResidueDetails
CNA*

SWS_FT_FI218ATP (Potential).
ChainResidueDetails
CNA*

SWS_FT_FI223For picornain 2A activity (By similarity).
ChainResidueDetails
DNA*
DNA*
DNA*

SWS_FT_FI232For picornain 3C activity (Potential).
ChainResidueDetails
DNA*
DNA*

SWS_FT_FI241For picornain 3C activity (By similarity).
ChainResidueDetails
DNA*

SWS_FT_FI2512Cleavage; by picornain 3C (Potential).
ChainResidueDetails
DNA*
DNA*
DNA*
DNA*
DNA*
DNA*

SWS_FT_FI262Cleavage (Potential).
ChainResidueDetails
DNA*

SWS_FT_FI272Cleavage; by picornain 2A (Potential).
ChainResidueDetails
DNA*

SWS_FT_FI288ATP (Potential).
ChainResidueDetails
DNA*

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Catalytic Information from CSA

site_idNumber of ResiduesDetails