1NCC
CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE-ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| N | 0004308 | molecular_function | exo-alpha-sialidase activity |
| N | 0005975 | biological_process | carbohydrate metabolic process |
| N | 0016020 | cellular_component | membrane |
| N | 0033644 | cellular_component | host cell membrane |
| N | 0046761 | biological_process | viral budding from plasma membrane |
| N | 0055036 | cellular_component | virion membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 378 |
| Details | Region: {"description":"Head of neuraminidase","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23429702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7549872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8371267","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9342319","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23429702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7549872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9342319","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 92 |
| Details | Domain: {"description":"Ig-like 1"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| N | ASP151 | |
| N | GLU277 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| N | GLU277 | |
| N | ASP151 | |
| N | ARG220 | |
| N | TRP412 | |
| N | ARG371 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 828 |
| Chain | Residue | Details |
