1NBU

7,8-Dihydroneopterin Aldolase Complexed with Product From Mycobacterium Tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004150	molecular_function	dihydroneopterin aldolase activity
A	0006760	biological_process	folic acid-containing compound metabolic process
B	0004150	molecular_function	dihydroneopterin aldolase activity
B	0006760	biological_process	folic acid-containing compound metabolic process
C	0004150	molecular_function	dihydroneopterin aldolase activity
C	0006760	biological_process	folic acid-containing compound metabolic process
D	0004150	molecular_function	dihydroneopterin aldolase activity
D	0006760	biological_process	folic acid-containing compound metabolic process
E	0004150	molecular_function	dihydroneopterin aldolase activity
E	0006760	biological_process	folic acid-containing compound metabolic process
F	0004150	molecular_function	dihydroneopterin aldolase activity
F	0006760	biological_process	folic acid-containing compound metabolic process
G	0004150	molecular_function	dihydroneopterin aldolase activity
G	0006760	biological_process	folic acid-containing compound metabolic process
H	0004150	molecular_function	dihydroneopterin aldolase activity
H	0006760	biological_process	folic acid-containing compound metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PH2 C 120

Chain	Residue
A	THR51
C	ILE73
C	GLU74
C	LYS99
C	HOH9166
A	TYR52
A	ASP53
A	TYR54
A	VAL55
C	GLY17
C	VAL18
C	GLU22
C	LEU72

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PH2 D 220

Chain	Residue
B	LEU48
B	THR51
B	TYR52
B	ASP53
B	TYR54
B	VAL55
D	GLY17
D	VAL18
D	GLU22
D	LEU72
D	ILE73
D	GLU74
D	LYS99
D	HOH9116

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PH2 B 320

Chain	Residue
B	GLY17
B	VAL18
B	GLU22
B	LEU72
B	ILE73
B	GLU74
B	LYS99
B	HOH9023
C	THR51
C	TYR52
C	ASP53
C	TYR54
C	VAL55

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PH2 A 420

Chain	Residue
A	GLY17
A	VAL18
A	GLU22
A	LEU72
A	ILE73
A	GLU74
A	LYS99
A	HOH9140
D	LEU48
D	THR51
D	TYR52
D	ASP53
D	TYR54
D	VAL55

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PH2 G 520

Chain	Residue
E	LEU48
E	THR51
E	TYR52
E	ASP53
E	TYR54
E	VAL55
G	GLY17
G	VAL18
G	GLU22
G	LEU72
G	ILE73
G	GLU74
G	LYS99
G	HOH9047

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PH2 H 620

Chain	Residue
F	LEU48
F	THR51
F	TYR52
F	ASP53
F	TYR54
F	VAL55
F	HOH9340
H	GLY17
H	VAL18
H	GLU22
H	LEU72
H	ILE73
H	GLU74
H	LYS99
H	HOH9005

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PH2 F 720

Chain	Residue
F	GLY17
F	VAL18
F	GLU22
F	LEU72
F	ILE73
F	GLU74
F	LYS99
F	HOH9017
G	LEU48
G	THR51
G	TYR52
G	ASP53
G	TYR54
G	VAL55

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PH2 E 820

Chain	Residue
E	GLU22
E	LEU72
E	ILE73
E	GLU74
E	LYS99
E	HOH9003
H	LEU48
H	THR51
H	TYR52
H	ASP53
H	TYR54
H	VAL55
E	GLY17
E	VAL18

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P56740","evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15876368","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1NBU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
F	GLU22
F	LYS99

---

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
A	GLU22
A	LYS99

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
E	GLU22
E	LYS99

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
G	GLU22
G	LYS99

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
H	GLU22
H	LYS99

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
B	GLU22
B	LYS99

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
D	GLU22
D	LYS99

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 2dhn

Chain	Residue	Details
C	GLU22
C	LYS99

---