Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
A | 0016579 | biological_process | protein deubiquitination |
B | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
B | 0016579 | biological_process | protein deubiquitination |
E | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
E | 0016579 | biological_process | protein deubiquitination |
Functional Information from PROSITE/UniProt
site_id | PS00299 |
Number of Residues | 26 |
Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
Chain | Residue | Details |
C | LYS327-ASP352 | |
site_id | PS00972 |
Number of Residues | 16 |
Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLknqGAtCYMNSlLQ |
Chain | Residue | Details |
A | GLY215-GLN230 | |
site_id | PS00973 |
Number of Residues | 18 |
Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YiLhAVlvHsGdnhg..GHY |
Chain | Residue | Details |
A | TYR448-TYR465 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | SITE: Interacts with activating enzyme |
Chain | Residue | Details |
C | ARG354 | |
C | ARG372 | |
D | ARG354 | |
D | ARG372 | |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | SITE: Essential for function |
Chain | Residue | Details |
C | HIS368 | |
D | HIS368 | |
E | HIS464 | |
Chain | Residue | Details |
C | SER365 | |
D | SER365 | |
Chain | Residue | Details |
C | THR366 | |
D | THR366 | |
Chain | Residue | Details |
C | GLZ376 | |
D | GLZ376 | |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
Chain | Residue | Details |
C | LYS306 | |
D | LYS306 | |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
C | GLZ376 | |
D | GLZ376 | |
Chain | Residue | Details |
C | LYS311 | |
C | LYS348 | |
D | LYS311 | |
D | LYS348 | |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
Chain | Residue | Details |
C | LYS327 | |
D | LYS327 | |
Chain | Residue | Details |
C | LYS329 | |
D | LYS329 | |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
Chain | Residue | Details |
C | LYS333 | |
D | LYS333 | |
Chain | Residue | Details |
C | LYS363 | |
D | LYS363 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 5 |
Details | a catalytic site defined by CSA, PubMed 12507430 |
Chain | Residue | Details |
A | ASN218 | |
A | CYS223 | |
A | CYS223 | |
A | ASP481 | |
A | HIS464 | |
site_id | CSA2 |
Number of Residues | 5 |
Details | a catalytic site defined by CSA, PubMed 12507430 |
Chain | Residue | Details |
B | ASN218 | |
B | CYS223 | |
B | CYS223 | |
B | ASP481 | |
B | HIS464 | |
site_id | CSA3 |
Number of Residues | 5 |
Details | a catalytic site defined by CSA, PubMed 12507430 |
Chain | Residue | Details |
E | ASN218 | |
E | CYS223 | |
E | CYS223 | |
E | ASP481 | |
E | HIS464 | |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 789 |
Chain | Residue | Details |
A | ASN218 | electrostatic stabiliser |
A | CYS223 | nucleofuge, nucleophile, proton acceptor, proton donor |
A | HIS464 | proton acceptor, proton donor |
A | ASP481 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 789 |
Chain | Residue | Details |
B | ASN218 | electrostatic stabiliser |
B | CYS223 | nucleofuge, nucleophile, proton acceptor, proton donor |
B | HIS464 | proton acceptor, proton donor |
B | ASP481 | electrostatic stabiliser |
site_id | MCSA3 |
Number of Residues | 4 |
Details | M-CSA 789 |
Chain | Residue | Details |
E | ASN218 | electrostatic stabiliser |
E | CYS223 | nucleofuge, nucleophile, proton acceptor, proton donor |
E | HIS464 | proton acceptor, proton donor |
E | ASP481 | electrostatic stabiliser |