Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1N9G

Mitochondrial 2-enoyl thioester reductase Etr1p/Etr2p heterodimer from Candida tropicalis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0019166	molecular_function	trans-2-enoyl-CoA reductase (NADPH) activity
A	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0005739	cellular_component	mitochondrion
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0019166	molecular_function	trans-2-enoyl-CoA reductase (NADPH) activity
B	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0005739	cellular_component	mitochondrion
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0019166	molecular_function	trans-2-enoyl-CoA reductase (NADPH) activity
C	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0005739	cellular_component	mitochondrion
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0019166	molecular_function	trans-2-enoyl-CoA reductase (NADPH) activity
D	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
E	0005739	cellular_component	mitochondrion
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0019166	molecular_function	trans-2-enoyl-CoA reductase (NADPH) activity
E	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
F	0005739	cellular_component	mitochondrion
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0019166	molecular_function	trans-2-enoyl-CoA reductase (NADPH) activity
F	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 1531

Chain	Residue
D	THR162
D	ILE163
D	HOH1586
D	HOH1789

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1532

Chain	Residue
A	ARG222
A	ARG224
A	NAP2387
A	HOH2390
A	GLY197
A	GLY198
A	THR199
A	VAL220
A	ILE221

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 D 1533

Chain	Residue
D	GLY197
D	GLY198
D	THR199
D	VAL220
D	ILE221
D	ARG222
D	ARG224
D	HOH1613
D	HOH1669
D	HOH1818
D	HOH1826

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1534

Chain	Residue
C	GLY197
C	GLY198
C	THR199
C	ILE221
C	ARG222
C	ARG224

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 1535

Chain	Residue
B	GLY197
B	GLY198
B	THR199
B	ILE221
B	ARG222
B	NAP3387
B	HOH3417

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 E 1536

Chain	Residue
E	GLY197
E	GLY198
E	THR199
E	ILE221
E	ARG222
E	ARG224
E	NAP4387
E	HOH4399

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 F 1537

Chain	Residue
F	GLY197
F	GLY198
F	THR199
F	VAL220
F	ILE221
F	ARG222
F	ARG224
F	HOH1680
F	HOH1760

site_id	AC8
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAP A 2387

Chain	Residue
A	ASN172
A	THR175
A	THR199
A	SER200
A	ALA201
A	VAL202
A	ARG222
A	ARG224
A	VAL275
A	TYR296
A	GLY297
A	GLY298
A	MET299
A	PHE321
A	TRP322
A	VAL323
A	LYS381
A	SO41532
A	HOH2598

site_id	AC9
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAP B 3387

Chain	Residue
B	PRO69
B	ASN172
B	THR175
B	GLY197
B	THR199
B	SER200
B	ALA201
B	VAL202
B	ARG222
B	ARG224
B	VAL275
B	TYR296
B	GLY297
B	GLY298
B	MET299
B	SER300
B	PHE321
B	TRP322
B	VAL323
B	LYS381
B	SO41535
B	HOH3497
B	HOH3519
B	HOH3526
B	HOH3552
B	HOH3593

site_id	BC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAP E 4387

Chain	Residue
E	PRO69
E	ASN172
E	THR175
E	THR199
E	SER200
E	ALA201
E	VAL202
E	ARG222
E	ARG224
E	VAL275
E	TYR296
E	GLY297
E	MET299
E	PHE321
E	TRP322
E	VAL323
E	LYS381
E	SO41536
E	HOH4426
E	HOH4485
E	HOH4563
E	HOH4576
E	HOH4582

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q8WZM3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12890667","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"25867044","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12614607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12890667","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
A	TYR79

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
A	ASN73
A	SER70

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
C	ASN73
C	SER70

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
F	ASN73
F	SER70

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
C	TYR79

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
F	TYR79

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
B	TYR79

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
D	TYR79

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
E	TYR79

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
B	ASN73
B	SER70

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
D	ASN73
D	SER70

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
E	ASN73
E	SER70

site_id	MCSA1
Number of Residues	1
Details	M-CSA 620

Chain	Residue	Details
B	TYR79	electrostatic stabiliser, increase electrophilicity

site_id	MCSA2
Number of Residues	1
Details	M-CSA 620

Chain	Residue	Details
D	TYR79	electrostatic stabiliser, increase electrophilicity

site_id	MCSA3
Number of Residues	1
Details	M-CSA 620

Chain	Residue	Details
E	TYR79	electrostatic stabiliser, increase electrophilicity

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)