1N8M

Solution structure of Pi4, a four disulfide bridged scorpion toxin active on potassium channels

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008200	molecular_function	ion channel inhibitor activity
A	0015459	molecular_function	potassium channel regulator activity
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
A	0099106	molecular_function	ion channel regulator activity

Functional Information from PROSITE/UniProt

site_id	PS01138
Number of Residues	23
Details	SCORP_SHORT_TOXIN Scorpion short toxins signature. CyrpCqkrtgcpn.AKCInktCkC

Chain	Residue	Details
A	CYS12-CYS34

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	37
Details	Peptide: {"description":"Potassium channel toxin alpha-KTx 6.4","featureId":"PRO_0000044913","evidences":[{"source":"PubMed","id":"9655636","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	5
Details	Site: {"description":"Important for the interaction with Kv1.2/KCNA2 channel","evidences":[{"source":"PubMed","id":"12919322","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Basic residue of the functional dyad, important for the interaction with Kv1.2/KCNA2 channel","evidences":[{"source":"PubMed","id":"12919322","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Aromatic residue of the functional dyad, important for the interaction with Kv1.2/KCNA2 channel","evidences":[{"source":"PubMed","id":"12919322","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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