1N7G
Crystal Structure of the GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDP-rhamnose.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005525 | molecular_function | GTP binding |
A | 0005829 | cellular_component | cytosol |
A | 0008446 | molecular_function | GDP-mannose 4,6-dehydratase activity |
A | 0009826 | biological_process | unidimensional cell growth |
A | 0016829 | molecular_function | lyase activity |
A | 0019673 | biological_process | GDP-mannose metabolic process |
A | 0042350 | biological_process | GDP-L-fucose biosynthetic process |
A | 0042351 | biological_process | 'de novo' GDP-L-fucose biosynthetic process |
B | 0005525 | molecular_function | GTP binding |
B | 0005829 | cellular_component | cytosol |
B | 0008446 | molecular_function | GDP-mannose 4,6-dehydratase activity |
B | 0009826 | biological_process | unidimensional cell growth |
B | 0016829 | molecular_function | lyase activity |
B | 0019673 | biological_process | GDP-mannose metabolic process |
B | 0042350 | biological_process | GDP-L-fucose biosynthetic process |
B | 0042351 | biological_process | 'de novo' GDP-L-fucose biosynthetic process |
C | 0005525 | molecular_function | GTP binding |
C | 0005829 | cellular_component | cytosol |
C | 0008446 | molecular_function | GDP-mannose 4,6-dehydratase activity |
C | 0009826 | biological_process | unidimensional cell growth |
C | 0016829 | molecular_function | lyase activity |
C | 0019673 | biological_process | GDP-mannose metabolic process |
C | 0042350 | biological_process | GDP-L-fucose biosynthetic process |
C | 0042351 | biological_process | 'de novo' GDP-L-fucose biosynthetic process |
D | 0005525 | molecular_function | GTP binding |
D | 0005829 | cellular_component | cytosol |
D | 0008446 | molecular_function | GDP-mannose 4,6-dehydratase activity |
D | 0009826 | biological_process | unidimensional cell growth |
D | 0016829 | molecular_function | lyase activity |
D | 0019673 | biological_process | GDP-mannose metabolic process |
D | 0042350 | biological_process | GDP-L-fucose biosynthetic process |
D | 0042351 | biological_process | 'de novo' GDP-L-fucose biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 39 |
Details | BINDING SITE FOR RESIDUE NDP A 701 |
Chain | Residue |
A | GLY35 |
A | ALA114 |
A | ALA115 |
A | SER117 |
A | TYR128 |
A | VAL132 |
A | ALA160 |
A | GLY161 |
A | SER162 |
A | TYR185 |
A | LYS189 |
A | THR37 |
A | LEU212 |
A | ASN214 |
A | HIS215 |
A | ARG220 |
A | GDR801 |
A | HOH806 |
A | HOH807 |
A | HOH810 |
A | HOH820 |
A | HOH825 |
A | GLY38 |
A | HOH837 |
A | HOH838 |
A | HOH839 |
A | HOH847 |
A | HOH851 |
A | HOH929 |
A | HOH931 |
C | ARG61 |
C | SER62 |
C | SER63 |
A | GLN39 |
A | ASP40 |
A | ARG60 |
A | ASP91 |
A | LEU92 |
A | LEU113 |
site_id | AC2 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE NDP B 702 |
Chain | Residue |
A | GDR802 |
A | HOH862 |
B | GLY35 |
B | THR37 |
B | GLY38 |
B | GLN39 |
B | ASP40 |
B | ARG60 |
B | ASP91 |
B | LEU92 |
B | LEU113 |
B | ALA114 |
B | ALA115 |
B | SER117 |
B | TYR128 |
B | VAL132 |
B | ALA160 |
B | GLY161 |
B | SER162 |
B | TYR185 |
B | LYS189 |
B | LEU212 |
B | ASN214 |
B | HIS215 |
B | ARG220 |
B | HOH705 |
B | HOH706 |
B | HOH719 |
B | HOH721 |
B | HOH725 |
B | HOH728 |
B | HOH733 |
B | HOH743 |
B | HOH760 |
B | HOH778 |
D | ARG61 |
D | SER62 |
D | SER63 |
site_id | AC3 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE NDP C 703 |
Chain | Residue |
C | TYR185 |
C | LYS189 |
C | LEU212 |
C | ASN214 |
C | HIS215 |
C | ARG220 |
C | HOH704 |
C | HOH719 |
C | HOH723 |
C | HOH724 |
C | HOH726 |
C | HOH731 |
C | HOH737 |
C | HOH747 |
C | HOH748 |
C | HOH749 |
A | ARG61 |
A | SER62 |
A | SER63 |
A | GDR803 |
A | HOH854 |
C | GLY35 |
C | THR37 |
C | GLY38 |
C | GLN39 |
C | ASP40 |
C | ARG60 |
C | ASP91 |
C | LEU92 |
C | LEU113 |
C | ALA114 |
C | ALA115 |
C | SER117 |
C | TYR128 |
C | VAL132 |
C | ALA160 |
C | GLY161 |
C | SER162 |
site_id | AC4 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE NDP D 704 |
Chain | Residue |
B | ARG61 |
B | SER62 |
B | SER63 |
D | GLY35 |
D | THR37 |
D | GLY38 |
D | GLN39 |
D | ASP40 |
D | ARG60 |
D | ASP91 |
D | LEU92 |
D | LEU113 |
D | ALA114 |
D | ALA115 |
D | SER117 |
D | TYR128 |
D | VAL132 |
D | ALA160 |
D | GLY161 |
D | SER162 |
D | TYR185 |
D | LYS189 |
D | LEU212 |
D | ASN214 |
D | HIS215 |
D | ARG220 |
D | HOH708 |
D | HOH709 |
D | HOH712 |
D | HOH719 |
D | HOH720 |
D | HOH721 |
D | HOH731 |
D | HOH769 |
D | HOH779 |
D | HOH780 |
D | HOH795 |
D | HOH800 |
site_id | AC5 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE GDR A 801 |
Chain | Residue |
A | SER117 |
A | HIS118 |
A | VAL119 |
A | SER162 |
A | SER163 |
A | GLU164 |
A | TYR185 |
A | ASN214 |
A | ARG220 |
A | ASN223 |
A | PHE224 |
A | VAL225 |
A | LYS228 |
A | GLY247 |
A | ASN248 |
A | ALA251 |
A | ARG253 |
A | VAL287 |
A | TYR312 |
A | ARG314 |
A | GLU317 |
A | NDP701 |
A | HOH822 |
A | HOH823 |
A | HOH828 |
A | HOH832 |
A | HOH867 |
A | HOH922 |
A | HOH931 |
site_id | AC6 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE GDR A 802 |
Chain | Residue |
A | HOH858 |
A | HOH862 |
B | SER117 |
B | HIS118 |
B | VAL119 |
B | SER162 |
B | SER163 |
B | GLU164 |
B | TYR185 |
B | ASN214 |
B | ARG220 |
B | ASN223 |
B | PHE224 |
B | VAL225 |
B | LYS228 |
B | LEU246 |
B | GLY247 |
B | ASN248 |
B | ALA251 |
B | ARG253 |
B | VAL287 |
B | TYR312 |
B | ARG314 |
B | GLU317 |
B | NDP702 |
B | HOH737 |
B | HOH748 |
B | HOH751 |
B | HOH752 |
site_id | AC7 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE GDR A 803 |
Chain | Residue |
A | HOH854 |
A | HOH880 |
A | HOH916 |
C | SER117 |
C | HIS118 |
C | VAL119 |
C | SER162 |
C | SER163 |
C | GLU164 |
C | TYR185 |
C | ASN214 |
C | ARG220 |
C | ASN223 |
C | PHE224 |
C | VAL225 |
C | LYS228 |
C | LEU246 |
C | GLY247 |
C | ASN248 |
C | ALA251 |
C | ARG253 |
C | VAL287 |
C | TYR312 |
C | ARG314 |
C | GLU317 |
C | NDP703 |
C | HOH722 |
C | HOH735 |
C | HOH786 |
C | HOH830 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:12501186 |
Chain | Residue | Details |
A | SER162 | |
B | SER162 | |
C | SER162 | |
D | SER162 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | ACT_SITE: Nucleophile => ECO:0000305|PubMed:12501186 |
Chain | Residue | Details |
A | GLU164 | |
A | TYR185 | |
B | GLU164 | |
B | TYR185 | |
C | GLU164 | |
C | TYR185 | |
D | GLU164 | |
D | TYR185 |
site_id | SWS_FT_FI3 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12501186 |
Chain | Residue | Details |
A | GLY35 | |
B | ARG60 | |
B | ASP91 | |
B | LEU113 | |
B | TYR128 | |
B | LYS189 | |
B | HIS215 | |
B | ARG220 | |
C | GLY35 | |
C | ARG60 | |
C | ASP91 | |
A | ARG60 | |
C | LEU113 | |
C | TYR128 | |
C | LYS189 | |
C | HIS215 | |
C | ARG220 | |
D | GLY35 | |
D | ARG60 | |
D | ASP91 | |
D | LEU113 | |
D | TYR128 | |
A | ASP91 | |
D | LYS189 | |
D | HIS215 | |
D | ARG220 | |
A | LEU113 | |
A | TYR128 | |
A | LYS189 | |
A | HIS215 | |
A | ARG220 | |
B | GLY35 |
site_id | SWS_FT_FI4 |
Number of Residues | 28 |
Details | BINDING: BINDING => ECO:0000305|PubMed:12501186 |
Chain | Residue | Details |
A | SER117 | |
B | TYR185 | |
B | ASN214 | |
B | GLY247 | |
B | ARG253 | |
B | ARG314 | |
C | SER117 | |
C | SER162 | |
C | TYR185 | |
C | ASN214 | |
C | GLY247 | |
A | SER162 | |
C | ARG253 | |
C | ARG314 | |
D | SER117 | |
D | SER162 | |
D | TYR185 | |
D | ASN214 | |
D | GLY247 | |
D | ARG253 | |
D | ARG314 | |
A | TYR185 | |
A | ASN214 | |
A | GLY247 | |
A | ARG253 | |
A | ARG314 | |
B | SER117 | |
B | SER162 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
A | TYR185 | |
A | LYS189 | |
A | GLY161 |
site_id | CSA10 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
B | TYR185 | |
B | LYS189 | |
B | SER162 |
site_id | CSA11 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
C | TYR185 | |
C | LYS189 | |
C | SER162 |
site_id | CSA12 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
D | TYR185 | |
D | LYS189 | |
D | SER162 |
site_id | CSA13 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
A | ARG182 | |
A | LYS189 |
site_id | CSA14 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
B | ARG182 | |
B | LYS189 |
site_id | CSA15 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
C | ARG182 | |
C | LYS189 |
site_id | CSA16 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
D | ARG182 | |
D | LYS189 |
site_id | CSA17 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
A | TYR185 | |
A | LYS189 |
site_id | CSA18 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
B | TYR185 | |
B | LYS189 |
site_id | CSA19 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
C | TYR185 | |
C | LYS189 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
B | TYR185 | |
B | LYS189 | |
B | GLY161 |
site_id | CSA20 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
D | TYR185 | |
D | LYS189 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
C | TYR185 | |
C | LYS189 | |
C | GLY161 |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
D | TYR185 | |
D | LYS189 | |
D | GLY161 |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
A | TYR185 | |
A | GLU164 | |
A | LYS189 | |
A | SER162 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
B | TYR185 | |
B | GLU164 | |
B | LYS189 | |
B | SER162 |
site_id | CSA7 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
C | TYR185 | |
C | GLU164 | |
C | LYS189 | |
C | SER162 |
site_id | CSA8 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
D | TYR185 | |
D | GLU164 | |
D | LYS189 | |
D | SER162 |
site_id | CSA9 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1db3 |
Chain | Residue | Details |
A | TYR185 | |
A | LYS189 | |
A | SER162 |