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1N6O

Crystal Structure of Human Rab5a A30K mutant complex with GppNHp

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 201
ChainResidue
ASER34
ATHR52
AGNP200
AHOH301
AHOH302

site_idAC2
Number of Residues30
DetailsBINDING SITE FOR RESIDUE GNP A 200
ChainResidue
ALYS33
ASER34
ASER35
APHE45
AHIS46
AGLU47
AGLN49
ASER51
ATHR52
AGLY78
AASN133
ALYS134
AASP136
ALEU137
ASER163
AALA164
ALYS165
ALYS180
AMG201
AHOH301
AHOH302
AHOH303
AHOH304
AHOH333
AHOH341
AHOH400
ASER29
ALYS30
AVAL31
AGLY32

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE BME A 210
ChainResidue
AGLY15
AALA55
ACYS63
AASP65
AASP66
ATHR67
ATHR68

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:12433916, ECO:0000269|PubMed:14684892, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:20534488, ECO:0007744|PDB:1N6H, ECO:0007744|PDB:1N6L, ECO:0007744|PDB:1N6N, ECO:0007744|PDB:1N6O, ECO:0007744|PDB:1N6P, ECO:0007744|PDB:1N6R, ECO:0007744|PDB:1R2Q, ECO:0007744|PDB:1TU3, ECO:0007744|PDB:3MJH
ChainResidueDetails
AGLY27
AHIS46
AASP75
AASN133
ASER163

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by LRRK2 => ECO:0000269|PubMed:29125462
ChainResidueDetails
ASER84

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: (Microbial infection) N-beta-linked (GlcNAc) arginine => ECO:0000269|PubMed:32974215
ChainResidueDetails
AARG120

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN79

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
ALYS30

226707

PDB entries from 2024-10-30

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