Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1N6F

tricorn protease in complex with Z-Phe-diketo-Arg-Glu-Phe

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0016787	molecular_function	hydrolase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0016787	molecular_function	hydrolase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0016787	molecular_function	hydrolase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0016787	molecular_function	hydrolase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE DKT A 1214

Chain	Residue
A	ARG131
A	TYR962
A	ALA963
A	GLY964
A	SER965
A	ASP966
A	TRP988
A	GLY993
A	ILE994
A	THR995
A	PHE1011
A	ARG132
A	HOH1276
A	HOH1308
B	ASP936
A	TYR609
A	HIS746
A	TYR748
A	ASN915
A	GLY916
A	GLY917
A	GLY918

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE DKT B 1214

Chain	Residue
A	ASP936
B	ARG131
B	ARG132
B	TYR609
B	TYR748
B	ASN915
B	GLY916
B	GLY917
B	GLY918
B	TYR962
B	ALA963
B	GLY964
B	SER965
B	ASP966
B	TRP988
B	GLY993
B	ILE994
B	THR995
B	PHE1011

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE DKT C 1214

Chain	Residue
C	ARG131
C	ARG132
C	TYR609
C	HIS746
C	ASN915
C	GLY916
C	GLY917
C	GLY918
C	TYR962
C	ALA963
C	GLY964
C	SER965
C	ASP966
C	TRP988
C	GLY993
C	ILE994
C	THR995
C	PHE1011
C	HOH1224
C	HOH1276
C	HOH1281
D	ASP936

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE DKT D 1214

Chain	Residue
C	ASP936
D	ARG131
D	ARG132
D	TYR609
D	HIS746
D	TYR748
D	ASN915
D	GLY916
D	GLY917
D	GLY918
D	TYR962
D	ALA963
D	GLY964
D	SER965
D	ASP966
D	TRP988
D	GLY993
D	ILE994
D	THR995
D	PHE1011
D	HOH1225
D	HOH1282
D	HOH1284

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE DKT E 1214

Chain	Residue
E	ASP966
E	TRP988
E	GLY993
E	ILE994
E	THR995
E	PHE1011
E	HOH1273
F	ASP936
E	ARG131
E	ARG132
E	TYR609
E	HIS746
E	TYR748
E	ASN915
E	GLY916
E	GLY917
E	GLY918
E	TYR962
E	ALA963
E	GLY964
E	SER965

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE DKT F 1214

Chain	Residue
E	ASP936
F	ARG131
F	ARG132
F	TYR609
F	HIS746
F	TYR748
F	ASN915
F	GLY916
F	GLY917
F	GLY918
F	TYR962
F	ALA963
F	GLY964
F	SER965
F	ASP966
F	TRP988
F	GLY993
F	ILE994
F	THR995
F	PHE1011
F	HOH1219

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1626
Details	Region: {"description":"Six-bladed beta propeller","evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"Binds the substrate's C-terminus","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2094
Details	Region: {"description":"Seven-bladed beta propeller","evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	396
Details	Region: {"description":"C-1; helical bundle","evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	564
Details	Region: {"description":"PDZ-like","evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1230
Details	Region: {"description":"C-2; alpha-beta sandwich","evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	6
Details	Site: {"description":"Substrate specificity switch","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	6
Details	Site: {"description":"Transition state stabilizer; via amide nitrogen","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
A	SER965
A	HIS746
A	ASP966
A	GLY918

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
B	SER965
B	HIS746
B	ASP966
B	GLY918

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
C	SER965
C	HIS746
C	ASP966
C	GLY918

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
D	SER965
D	HIS746
D	ASP966
D	GLY918

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
E	SER965
E	HIS746
E	ASP966
E	GLY918

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
F	SER965
F	HIS746
F	ASP966
F	GLY918

site_id	MCSA1
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
A	HIS746	proton shuttle (general acid/base)
A	GLY918	electrostatic stabiliser
A	SER965	covalently attached
A	ASP966	electrostatic stabiliser

site_id	MCSA2
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
B	HIS746	proton shuttle (general acid/base)
B	GLY918	electrostatic stabiliser
B	SER965	covalently attached
B	ASP966	electrostatic stabiliser

site_id	MCSA3
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
C	HIS746	proton shuttle (general acid/base)
C	GLY918	electrostatic stabiliser
C	SER965	covalently attached
C	ASP966	electrostatic stabiliser

site_id	MCSA4
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
D	HIS746	proton shuttle (general acid/base)
D	GLY918	electrostatic stabiliser
D	SER965	covalently attached
D	ASP966	electrostatic stabiliser

site_id	MCSA5
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
E	HIS746	proton shuttle (general acid/base)
E	GLY918	electrostatic stabiliser
E	SER965	covalently attached
E	ASP966	electrostatic stabiliser

site_id	MCSA6
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
F	HIS746	proton shuttle (general acid/base)
F	GLY918	electrostatic stabiliser
F	SER965	covalently attached
F	ASP966	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)