Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1N6E

tricorn protease in complex with a tridecapeptide chloromethyl ketone derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0016787	molecular_function	hydrolase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0016787	molecular_function	hydrolase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0016787	molecular_function	hydrolase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0016787	molecular_function	hydrolase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE B 1214

Chain	Residue
A	HIS746
A	SER965
A	ASP966
B	PHE1213

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE D 1214

Chain	Residue
C	HIS746
C	SER965
C	ASP966
D	PHE1213

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE F 1214

Chain	Residue
E	SER965
E	ASP966
F	PHE1213
E	HIS746

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE H 1214

Chain	Residue
G	HIS746
G	SER965
G	ASP966
H	PHE1213

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE J 1214

Chain	Residue
I	HIS746
I	SER965
I	ASP966
J	PHE1213

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE L 1214

Chain	Residue
K	HIS746
K	SER965
K	ASP966
L	PHE1213

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1626
Details	Region: {"description":"Six-bladed beta propeller","evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"Binds the substrate's C-terminus","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2094
Details	Region: {"description":"Seven-bladed beta propeller","evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	396
Details	Region: {"description":"C-1; helical bundle","evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	564
Details	Region: {"description":"PDZ-like","evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1230
Details	Region: {"description":"C-2; alpha-beta sandwich","evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	6
Details	Site: {"description":"Substrate specificity switch","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	6
Details	Site: {"description":"Transition state stabilizer; via amide nitrogen","evidences":[{"source":"PubMed","id":"11719810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12470958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
A	SER965
A	HIS746
A	ASP966
A	GLY918

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
C	SER965
C	HIS746
C	ASP966
C	GLY918

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
E	SER965
E	HIS746
E	ASP966
E	GLY918

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
G	SER965
G	HIS746
G	ASP966
G	GLY918

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
I	SER965
I	HIS746
I	ASP966
I	GLY918

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
K	SER965
K	HIS746
K	ASP966
K	GLY918

site_id	MCSA1
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
A	HIS746	proton shuttle (general acid/base)
A	GLY918	electrostatic stabiliser
A	SER965	covalently attached
A	ASP966	electrostatic stabiliser

site_id	MCSA2
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
C	HIS746	proton shuttle (general acid/base)
C	GLY918	electrostatic stabiliser
C	SER965	covalently attached
C	ASP966	electrostatic stabiliser

site_id	MCSA3
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
E	HIS746	proton shuttle (general acid/base)
E	GLY918	electrostatic stabiliser
E	SER965	covalently attached
E	ASP966	electrostatic stabiliser

site_id	MCSA4
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
G	HIS746	proton shuttle (general acid/base)
G	GLY918	electrostatic stabiliser
G	SER965	covalently attached
G	ASP966	electrostatic stabiliser

site_id	MCSA5
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
I	HIS746	proton shuttle (general acid/base)
I	GLY918	electrostatic stabiliser
I	SER965	covalently attached
I	ASP966	electrostatic stabiliser

site_id	MCSA6
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
K	HIS746	proton shuttle (general acid/base)
K	GLY918	electrostatic stabiliser
K	SER965	covalently attached
K	ASP966	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)