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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1N6E

tricorn protease in complex with a tridecapeptide chloromethyl ketone derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0008236	molecular_function	serine-type peptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0008236	molecular_function	serine-type peptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0008236	molecular_function	serine-type peptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE B 1214

Chain	Residue
A	HIS746
A	SER965
A	ASP966
B	PHE1213

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE D 1214

Chain	Residue
C	HIS746
C	SER965
C	ASP966
D	PHE1213

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE F 1214

Chain	Residue
E	SER965
E	ASP966
F	PHE1213
E	HIS746

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE H 1214

Chain	Residue
G	HIS746
G	SER965
G	ASP966
H	PHE1213

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE J 1214

Chain	Residue
I	HIS746
I	SER965
I	ASP966
J	PHE1213

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 0QE L 1214

Chain	Residue
K	HIS746
K	SER965
K	ASP966
L	PHE1213

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000269\|PubMed:11719810, ECO:0000269\|PubMed:12470958

Chain	Residue	Details
A	HIS746
C	HIS746
E	HIS746
G	HIS746
I	HIS746
K	HIS746

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Nucleophile => ECO:0000269\|PubMed:11719810, ECO:0000269\|PubMed:12470958

Chain	Residue	Details
A	SER965
C	SER965
E	SER965
G	SER965
I	SER965
K	SER965

site_id	SWS_FT_FI3
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000269\|PubMed:11719810

Chain	Residue	Details
A	GLU1023
C	GLU1023
E	GLU1023
G	GLU1023
I	GLU1023
K	GLU1023

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:11719810, ECO:0000269\|PubMed:12470958

Chain	Residue	Details
A	GLY916
C	GLY916
E	GLY916
G	GLY916
I	GLY916
K	GLY916

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:12470958

Chain	Residue	Details
A	GLY993
C	GLY993
E	GLY993
G	GLY993
I	GLY993
K	GLY993

site_id	SWS_FT_FI6
Number of Residues	6
Details	SITE: Substrate specificity switch => ECO:0000269\|PubMed:11719810

Chain	Residue	Details
A	ASP936
C	ASP936
E	ASP936
G	ASP936
I	ASP936
K	ASP936

site_id	SWS_FT_FI7
Number of Residues	6
Details	SITE: Transition state stabilizer; via amide nitrogen => ECO:0000269\|PubMed:11719810, ECO:0000269\|PubMed:12470958

Chain	Residue	Details
A	ASP966
C	ASP966
E	ASP966
G	ASP966
I	ASP966
K	ASP966

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
A	SER965
A	HIS746
A	ASP966
A	GLY918

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
C	SER965
C	HIS746
C	ASP966
C	GLY918

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
E	SER965
E	HIS746
E	ASP966
E	GLY918

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
G	SER965
G	HIS746
G	ASP966
G	GLY918

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
I	SER965
I	HIS746
I	ASP966
I	GLY918

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1k32

Chain	Residue	Details
K	SER965
K	HIS746
K	ASP966
K	GLY918

site_id	MCSA1
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
A	HIS746	proton shuttle (general acid/base)
A	GLY918	electrostatic stabiliser
A	SER965	covalently attached
A	ASP966	electrostatic stabiliser

site_id	MCSA2
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
C	HIS746	proton shuttle (general acid/base)
C	GLY918	electrostatic stabiliser
C	SER965	covalently attached
C	ASP966	electrostatic stabiliser

site_id	MCSA3
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
E	HIS746	proton shuttle (general acid/base)
E	GLY918	electrostatic stabiliser
E	SER965	covalently attached
E	ASP966	electrostatic stabiliser

site_id	MCSA4
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
G	HIS746	proton shuttle (general acid/base)
G	GLY918	electrostatic stabiliser
G	SER965	covalently attached
G	ASP966	electrostatic stabiliser

site_id	MCSA5
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
I	HIS746	proton shuttle (general acid/base)
I	GLY918	electrostatic stabiliser
I	SER965	covalently attached
I	ASP966	electrostatic stabiliser

site_id	MCSA6
Number of Residues	4
Details	M-CSA 808

Chain	Residue	Details
K	HIS746	proton shuttle (general acid/base)
K	GLY918	electrostatic stabiliser
K	SER965	covalently attached
K	ASP966	electrostatic stabiliser

221716

PDB entries from 2024-06-26

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