1N1E
Crystal structure of Leishmania mexicana Glycerol-3-phosphate dehydrogenase complexed with DHAP and NAD
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0020015 | cellular_component | glycosome |
A | 0046168 | biological_process | glycerol-3-phosphate catabolic process |
A | 0051287 | molecular_function | NAD binding |
A | 0141152 | molecular_function | glycerol-3-phosphate dehydrogenase (NAD+) activity |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0020015 | cellular_component | glycosome |
B | 0046168 | biological_process | glycerol-3-phosphate catabolic process |
B | 0051287 | molecular_function | NAD binding |
B | 0141152 | molecular_function | glycerol-3-phosphate dehydrogenase (NAD+) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 35 |
Details | BINDING SITE FOR RESIDUE NDE A 400 |
Chain | Residue |
A | SER23 |
A | PHE97 |
A | THR124 |
A | LYS125 |
A | GLY153 |
A | SER155 |
A | PHE156 |
A | ALA157 |
A | LYS210 |
A | ASN211 |
A | THR267 |
A | GLY24 |
A | SER273 |
A | ARG274 |
A | ASN275 |
A | ALA297 |
A | VAL298 |
A | GLU300 |
A | HOH428 |
A | HOH460 |
A | HOH463 |
A | HOH466 |
A | ALA25 |
A | HOH467 |
A | HOH469 |
A | HOH471 |
A | HOH486 |
A | HOH525 |
A | HOH535 |
A | PHE26 |
A | HIS45 |
A | MET46 |
A | PHE63 |
A | VAL92 |
A | PRO94 |
site_id | AC2 |
Number of Residues | 31 |
Details | BINDING SITE FOR RESIDUE NDE B 401 |
Chain | Residue |
B | SER23 |
B | GLY24 |
B | ALA25 |
B | PHE26 |
B | HIS45 |
B | PHE63 |
B | VAL92 |
B | PRO94 |
B | PHE97 |
B | THR124 |
B | LYS125 |
B | GLY153 |
B | SER155 |
B | PHE156 |
B | ALA157 |
B | LYS210 |
B | ASN211 |
B | THR267 |
B | SER273 |
B | ARG274 |
B | ASN275 |
B | ALA297 |
B | VAL298 |
B | GLU300 |
B | HOH417 |
B | HOH468 |
B | HOH473 |
B | HOH475 |
B | HOH479 |
B | HOH525 |
B | HOH560 |
Functional Information from PROSITE/UniProt
site_id | PS00957 |
Number of Residues | 22 |
Details | NAD_G3PDH NAD-dependent glycerol-3-phosphate dehydrogenase signature. SAVKNVLAiGsGVanGLgMGlN |
Chain | Residue | Details |
A | SER207-ASN228 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000305 |
Chain | Residue | Details |
A | LYS210 | |
B | LYS210 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10801498, ECO:0000269|PubMed:12758080 |
Chain | Residue | Details |
A | GLY22 | |
A | ALA157 | |
A | VAL298 | |
A | GLU300 | |
B | GLY22 | |
B | ALA157 | |
B | VAL298 | |
B | GLU300 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | PHE97 | |
A | ARG274 | |
B | PHE97 | |
B | ARG274 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12758080 |
Chain | Residue | Details |
A | LYS125 | |
B | LYS125 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1evy |
Chain | Residue | Details |
A | LYS210 | |
A | THR267 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1evy |
Chain | Residue | Details |
B | LYS210 | |
B | THR267 |
site_id | MCSA1 |
Number of Residues | 2 |
Details | M-CSA 593 |
Chain | Residue | Details |
A | LYS210 | proton acceptor, proton donor |
A | THR267 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 2 |
Details | M-CSA 593 |
Chain | Residue | Details |
B | LYS210 | proton acceptor, proton donor |
B | THR267 | electrostatic stabiliser |