1N0N

Catalytic and Structural Effects of Amino-Acid Substitution at His30 in Human Manganese Superoxide Dismutase

Replaces:  1LUS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004784	molecular_function	superoxide dismutase activity
A	0006801	biological_process	superoxide metabolic process
A	0046872	molecular_function	metal ion binding
B	0004784	molecular_function	superoxide dismutase activity
B	0006801	biological_process	superoxide metabolic process
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 199

Chain	Residue
A	HIS26
A	HIS74
A	ASP159
A	HIS163
A	HOH769

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 601

Chain	Residue
A	HOH762
A	HIS2
A	SER3
A	HIS71
A	HOH726

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 602

Chain	Residue
A	ALA63
A	ASN67
A	GLN119
A	HOH628
A	HOH724
A	HOH767

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN B 199

Chain	Residue
B	HIS26
B	HIS74
B	ASP159
B	HIS163
B	HOH872

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 701

Chain	Residue
A	LYS178
B	HIS2
B	SER3
B	HIS71
B	HOH862

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 702

Chain	Residue
B	ASN37
B	ALA63
B	ASN67
B	GLN119
B	HOH717
B	HOH720
B	HOH762
B	HOH858

---

Functional Information from PROSITE/UniProt

site_id	PS00088
Number of Residues	8
Details	SOD_MN Manganese and iron superoxide dismutases signature. DvWEHAYY

Chain	Residue	Details
A	ASP159-TYR166

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10852710","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11580280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1394426","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19265433","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9537987","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9537988","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JA8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1AP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AP6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N0J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZSP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZTE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2P4K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"PubMed","id":"10334867","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16399855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P09671","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P09671","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---