1N0I

Crystal Structure of Ferrochelatase with Cadmium bound at active site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004325	molecular_function	ferrochelatase activity
A	0005737	cellular_component	cytoplasm
A	0006783	biological_process	heme biosynthetic process
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 910

Chain	Residue
A	TYR13
A	HIS183
A	SER222
A	GLU264
A	HOH982
A	HOH1052

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 911

Chain	Residue
A	HOH962
A	HOH1264
A	HIS262
A	HOH924
A	HOH960

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 912

Chain	Residue
A	GLU145
A	LYS307

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 913

Chain	Residue
A	ARG33
A	PHE117
A	SER146
A	GLN199

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 900

Chain	Residue
A	HOH1266
A	HOH1267
A	HOH1268
A	HOH1269
A	HOH1270
A	HOH1271

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 901

Chain	Residue
A	HOH1272
A	HOH1273
A	HOH1274
A	HOH1275
A	HOH1276
A	HOH1277

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 902

Chain	Residue
A	GLU20
A	HOH1278
A	HOH1279
A	HOH1280
A	HOH1281
A	HOH1282

---

Functional Information from PROSITE/UniProt

site_id	PS00534
Number of Residues	19
Details	FERROCHELATASE Ferrochelatase signature. LIvSaHSLPekik.EfGDp...Y

Chain	Residue	Details
A	LEU178-TYR196

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:10704318, ECO:0007744|PDB:1C1H

Chain	Residue	Details
A	TYR13
A	ARG31
A	HIS183
A	LYS188

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:17198378, ECO:0000305|PubMed:21052751

Chain	Residue	Details
A	GLU20

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00323

Chain	Residue	Details
A	ARG30
A	SER54
A	TYR125

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:12761666

Chain	Residue	Details
A	ARG46
A	ASP268
A	GLU272

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00323, ECO:0000305|PubMed:12761666, ECO:0000305|PubMed:16140324, ECO:0000305|PubMed:17198378, ECO:0000305|PubMed:21052751

Chain	Residue	Details
A	GLU264

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1hrk

Chain	Residue	Details
A	GLU264
A	HIS262
A	HIS183

---