1MZJ
Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| A | 0044550 | biological_process | secondary metabolite biosynthetic process |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| B | 0044550 | biological_process | secondary metabolite biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE COA A 500 |
| Chain | Residue |
| A | SER37 |
| A | MET220 |
| A | GLY222 |
| A | LYS223 |
| A | PHE226 |
| A | ALA259 |
| A | ASN260 |
| A | GLU275 |
| A | ASN288 |
| A | ACE502 |
| A | HOH658 |
| A | TRP41 |
| A | HOH683 |
| A | HOH688 |
| A | ARG45 |
| A | CYS121 |
| A | ARG160 |
| A | PHE164 |
| A | LEU165 |
| A | PHE166 |
| A | LEU198 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE COA B 501 |
| Chain | Residue |
| B | ASP36 |
| B | SER37 |
| B | TRP41 |
| B | ARG45 |
| B | CYS121 |
| B | ARG160 |
| B | PHE164 |
| B | PHE166 |
| B | MET220 |
| B | GLY222 |
| B | HIS257 |
| B | ALA259 |
| B | ASN260 |
| B | ASN288 |
| B | ACE503 |
| B | HOH543 |
| B | HOH633 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACE A 502 |
| Chain | Residue |
| A | ALA120 |
| A | CYS121 |
| A | ALA320 |
| A | COA500 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACE B 503 |
| Chain | Residue |
| B | ALA120 |
| B | CYS121 |
| B | GLY319 |
| B | ALA320 |
| B | COA501 |
Functional Information from PROSITE/UniProt
| site_id | PS00626 |
| Number of Residues | 11 |
| Details | RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. ACAGfCHALSI |
| Chain | Residue | Details |
| A | ALA120-ILE130 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01815, ECO:0000305|PubMed:12429097 |
| Chain | Residue | Details |
| A | CYS121 | |
| A | HIS257 | |
| A | ASN288 | |
| B | CYS121 | |
| B | HIS257 | |
| B | ASN288 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| A | CYS121 | |
| A | HIS257 | |
| A | PHE166 | |
| A | ASN288 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cgk |
| Chain | Residue | Details |
| B | CYS121 | |
| B | HIS257 | |
| B | PHE166 | |
| B | ASN288 |
