1MYJ
DISTAL POLARITY IN LIGAND BINDING TO MYOGLOBIN: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A THREONINE68(E11) MUTANT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003009 | biological_process | skeletal muscle contraction |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005344 | molecular_function | oxygen carrier activity |
| A | 0015671 | biological_process | oxygen transport |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016528 | cellular_component | sarcoplasm |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0019825 | molecular_function | oxygen binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0098809 | molecular_function | nitrite reductase activity |
| B | 0003009 | biological_process | skeletal muscle contraction |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005344 | molecular_function | oxygen carrier activity |
| B | 0015671 | biological_process | oxygen transport |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016528 | cellular_component | sarcoplasm |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0019825 | molecular_function | oxygen binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0098809 | molecular_function | nitrite reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 154 |
| Chain | Residue |
| B | HIS64 |
| B | THR67 |
| B | HOH195 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 154 |
| Chain | Residue |
| A | HIS64 |
| A | THR67 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HEM A 155 |
| Chain | Residue |
| A | ALA71 |
| A | LEU89 |
| A | SER92 |
| A | HIS93 |
| A | HIS97 |
| A | ILE99 |
| A | TYR103 |
| A | PHE138 |
| A | HOH190 |
| A | HOH208 |
| A | LYS42 |
| A | PHE43 |
| A | HIS64 |
| A | THR68 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HEM B 155 |
| Chain | Residue |
| B | LYS42 |
| B | PHE43 |
| B | HIS64 |
| B | THR68 |
| B | ALA71 |
| B | LEU89 |
| B | SER92 |
| B | HIS93 |
| B | HIS97 |
| B | ILE99 |
| B | TYR103 |
| B | PHE138 |
| B | HOH164 |
| B | HOH187 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 292 |
| Details | Domain: {"description":"Globin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9843395","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MNO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"2383370","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9843395","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MDN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MNI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MWC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MWD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MYG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MYH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YCB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9QZ76","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P04247","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
