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1MXE

Structure of the Complex of Calmodulin with the Target Sequence of CaMKI

Functional Information from GO Data
ChainGOidnamespacecontents
A0000226biological_processmicrotubule cytoskeleton organization
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005814cellular_componentcentriole
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007099biological_processcentriole replication
A0007605biological_processsensory perception of sound
A0007608biological_processsensory perception of smell
A0016028cellular_componentrhabdomere
A0016056biological_processG protein-coupled opsin signaling pathway
A0016059biological_processnegative regulation of opsin-mediated signaling pathway
A0016060biological_processnegative regulation of phospholipase C-activating phototransduction signaling pathway
A0016247molecular_functionchannel regulator activity
A0030048biological_processactin filament-based movement
A0030234molecular_functionenzyme regulator activity
A0030496cellular_componentmidbody
A0031475cellular_componentmyosin V complex
A0031476cellular_componentmyosin VI complex
A0031477cellular_componentmyosin VII complex
A0031489molecular_functionmyosin V binding
A0032036molecular_functionmyosin heavy chain binding
A0042052biological_processrhabdomere development
A0046716biological_processmuscle cell cellular homeostasis
A0046872molecular_functionmetal ion binding
A0048102biological_processautophagic cell death
A0050911biological_processdetection of chemical stimulus involved in sensory perception of smell
A0051383biological_processkinetochore organization
A0070855molecular_functionmyosin VI head/neck binding
A0071361biological_processcellular response to ethanol
A0072499biological_processphotoreceptor cell axon guidance
A0072686cellular_componentmitotic spindle
A0097431cellular_componentmitotic spindle pole
B0000226biological_processmicrotubule cytoskeleton organization
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005814cellular_componentcentriole
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0007099biological_processcentriole replication
B0007605biological_processsensory perception of sound
B0007608biological_processsensory perception of smell
B0016028cellular_componentrhabdomere
B0016056biological_processG protein-coupled opsin signaling pathway
B0016059biological_processnegative regulation of opsin-mediated signaling pathway
B0016060biological_processnegative regulation of phospholipase C-activating phototransduction signaling pathway
B0016247molecular_functionchannel regulator activity
B0030048biological_processactin filament-based movement
B0030234molecular_functionenzyme regulator activity
B0030496cellular_componentmidbody
B0031475cellular_componentmyosin V complex
B0031476cellular_componentmyosin VI complex
B0031477cellular_componentmyosin VII complex
B0031489molecular_functionmyosin V binding
B0032036molecular_functionmyosin heavy chain binding
B0042052biological_processrhabdomere development
B0046716biological_processmuscle cell cellular homeostasis
B0046872molecular_functionmetal ion binding
B0048102biological_processautophagic cell death
B0050911biological_processdetection of chemical stimulus involved in sensory perception of smell
B0051383biological_processkinetochore organization
B0070855molecular_functionmyosin VI head/neck binding
B0071361biological_processcellular response to ethanol
B0072499biological_processphotoreceptor cell axon guidance
B0072686cellular_componentmitotic spindle
B0097431cellular_componentmitotic spindle pole
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 501
ChainResidue
BASP129
BASP131
BASP133
BGLN135
BGLU140
BHOH575

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CA B 502
ChainResidue
BTHR62
BGLU67
BHOH540
BHOH562
BASP56
BASP58
BASN60

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 503
ChainResidue
BASP20
BASP22
BASP24
BTHR26
BGLU31
BHOH507

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 504
ChainResidue
BASP93
BASP95
BASN97
BPHE99
BGLU104
BHOH523

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 505
ChainResidue
AASP93
AASP95
AASN97
APHE99
AGLU104
AHOH516

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 506
ChainResidue
AASP129
AASP131
AASP133
AGLN135
AGLU140
AHOH515

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 507
ChainResidue
AASP56
AASP58
AASN60
ATHR62
AGLU67
AHOH625

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 508
ChainResidue
AASP20
AASP22
AASP24
ATHR26
AGLU31
AHOH518

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
AASP20-LEU32
AASP56-PHE68
AASP93-LEU105
AASP129-PHE141

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues70
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues70
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues70
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues38
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsSite: {"description":"Not N6-methylated"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"PubMed","id":"17610210","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues42
DetailsRegion: {"description":"Calmodulin-binding","evidences":[{"source":"PubMed","id":"12475216","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2L7L","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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