1MVX

structure of the SET domain histone lysine methyltransferase Clr4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0008270	molecular_function	zinc ion binding
A	0042054	molecular_function	histone methyltransferase activity
A	0046974	molecular_function	histone H3K9 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 601

Chain	Residue
A	GLN257
A	ASN308
A	SER309
A	ARG423

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS260
A	CYS278
A	CYS307
A	CYS311

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS307
A	CYS313
A	CYS317
A	CYS268

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	CYS260
A	CYS262
A	CYS268
A	CYS276

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI A 504

Chain	Residue
A	ARG206
A	ARG206
A	ARG210
A	ARG210

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	67
Details	Domain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	124
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12389037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30051891","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30051891","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; by autocatalysis; alternate","evidences":[{"source":"PubMed","id":"30051891","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---