1MVN
PPC decarboxylase mutant C175S complexed with pantothenoylaminoethenethiol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004633 | molecular_function | phosphopantothenoylcysteine decarboxylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0010181 | molecular_function | FMN binding |
| A | 0015937 | biological_process | coenzyme A biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0042538 | biological_process | hyperosmotic salinity response |
| A | 0071513 | cellular_component | phosphopantothenoylcysteine decarboxylase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PCO A 1001 |
| Chain | Residue |
| A | VAL30 |
| A | ALA174 |
| A | GLY181 |
| A | ALA182 |
| A | MET183 |
| A | FMN1002 |
| A | HOH1018 |
| A | ALA31 |
| A | LYS34 |
| A | HIS90 |
| A | ILE91 |
| A | MET141 |
| A | ASN142 |
| A | ARG172 |
| A | LEU173 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE FMN A 1002 |
| Chain | Residue |
| A | SER27 |
| A | GLY28 |
| A | SER29 |
| A | VAL30 |
| A | THR53 |
| A | SER55 |
| A | PHE59 |
| A | TRP78 |
| A | TRP81 |
| A | SER106 |
| A | ALA107 |
| A | ASN108 |
| A | THR109 |
| A | CYS118 |
| A | ASP119 |
| A | CYS124 |
| A | ALA140 |
| A | MET141 |
| A | PCO1001 |
| A | HOH1006 |
| A | HOH1007 |
| A | HOH1010 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11279129","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12614618","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MVN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"12614618","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1MVN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10986463","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12614618","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E20","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MVL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12614618","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1MVN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"12614618","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1MVN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 11279129, 12614618 |
| Chain | Residue | Details |
| A | SER175 | |
| A | HIS90 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 639 |
| Chain | Residue | Details |
| A | HIS90 | electrostatic stabiliser, proton acceptor |
| A | SER175 | proton donor |
