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1MU9

Crystal Structure of a Human Tyrosyl-DNA Phosphodiesterase (Tdp1)-Vanadate Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0006281biological_processDNA repair
A0008081molecular_functionphosphoric diester hydrolase activity
B0005634cellular_componentnucleus
B0006281biological_processDNA repair
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE VO4 A 609
ChainResidue
AHIS263
ALYS265
AASN283
AHIS493
ALYS495
AASN516
AGOL610
AHOH703

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 610
ChainResidue
AGLY458
AHIS493
AVO4609
AHOH703
AHIS263

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE VO4 B 609
ChainResidue
BHIS263
BLYS265
BASN283
BHIS493
BLYS495
BASN516
BGOL610

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 610
ChainResidue
BHIS263
BHIS493
BVO4609
BHOH896
BHOH989

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:12470949, ECO:0000269|PubMed:15111055
ChainResidueDetails
AHIS263
BHIS263

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:12470949, ECO:0000269|PubMed:15111055
ChainResidueDetails
AHIS493
BHIS493

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:12470949
ChainResidueDetails
ALYS265
ALYS495
BLYS265
BLYS495

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Interaction with DNA => ECO:0000269|PubMed:12470949
ChainResidueDetails
ASER518
BSER518

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PDB entries from 2024-11-06

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