1MTQ

THREE-DIMENSIONAL SOLUTION STRUCTURE OF ALPHA-CONOTOXIN GID BY NMR SPECTROSCOPY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0030550	molecular_function	acetylcholine receptor inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS60014
Number of Residues	15
Details	ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCSnPACRvnnpHVC

Chain	Residue	Details
A	CYS5-CYS19

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Key residue for activity on alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR => ECO:0000269|PubMed:19098004, ECO:0000269|PubMed:24122487

Chain	Residue	Details
A	ASP3

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Key residue for activity on alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR => ECO:0000269|PubMed:19098004

Chain	Residue	Details
A	PRO9

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Important for determining subtype selectivity => ECO:0000269|PubMed:24122487

Chain	Residue	Details
A	ALA10
A	VAL13

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Key residue for activity on alpha-7/CHRNA7 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR => ECO:0000269|PubMed:12419800, ECO:0000269|PubMed:19098004

Chain	Residue	Details
A	ARG12

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Key residue for activity on alpha-7/CHRNA7 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR => ECO:0000269|PubMed:19098004

Chain	Residue	Details
A	ASN14

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: 4-carboxyglutamate => ECO:0000269|PubMed:12419800

Chain	Residue	Details
A	CGU4

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: 4-hydroxyproline => ECO:0000269|PubMed:12419800

Chain	Residue	Details
A	HYP16

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