Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1MR8

MIGRATION INHIBITORY FACTOR-RELATED PROTEIN 8 FROM HUMAN

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0002523biological_processleukocyte migration involved in inflammatory response
A0002544biological_processchronic inflammatory response
A0002790biological_processpeptide secretion
A0002793biological_processpositive regulation of peptide secretion
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006914biological_processautophagy
A0006915biological_processapoptotic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0008017molecular_functionmicrotubule binding
A0008270molecular_functionzinc ion binding
A0010043biological_processresponse to zinc ion
A0014002biological_processastrocyte development
A0016020cellular_componentmembrane
A0018119biological_processpeptidyl-cysteine S-nitrosylation
A0030307biological_processpositive regulation of cell growth
A0030593biological_processneutrophil chemotaxis
A0032119biological_processsequestering of zinc ion
A0032496biological_processresponse to lipopolysaccharide
A0034121biological_processregulation of toll-like receptor signaling pathway
A0034774cellular_componentsecretory granule lumen
A0035425biological_processautocrine signaling
A0035662molecular_functionToll-like receptor 4 binding
A0042742biological_processdefense response to bacterium
A0045087biological_processinnate immune response
A0045111cellular_componentintermediate filament cytoskeleton
A0045471biological_processresponse to ethanol
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0050544molecular_functionarachidonic acid binding
A0050729biological_processpositive regulation of inflammatory response
A0050786molecular_functionRAGE receptor binding
A0050832biological_processdefense response to fungus
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051493biological_processregulation of cytoskeleton organization
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070488biological_processneutrophil aggregation
A1990660cellular_componentcalprotectin complex
A2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
B0002376biological_processimmune system process
B0002523biological_processleukocyte migration involved in inflammatory response
B0002544biological_processchronic inflammatory response
B0002790biological_processpeptide secretion
B0002793biological_processpositive regulation of peptide secretion
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006914biological_processautophagy
B0006915biological_processapoptotic process
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0008017molecular_functionmicrotubule binding
B0008270molecular_functionzinc ion binding
B0010043biological_processresponse to zinc ion
B0014002biological_processastrocyte development
B0016020cellular_componentmembrane
B0018119biological_processpeptidyl-cysteine S-nitrosylation
B0030307biological_processpositive regulation of cell growth
B0030593biological_processneutrophil chemotaxis
B0032119biological_processsequestering of zinc ion
B0032496biological_processresponse to lipopolysaccharide
B0034121biological_processregulation of toll-like receptor signaling pathway
B0034774cellular_componentsecretory granule lumen
B0035425biological_processautocrine signaling
B0035662molecular_functionToll-like receptor 4 binding
B0042742biological_processdefense response to bacterium
B0045087biological_processinnate immune response
B0045111cellular_componentintermediate filament cytoskeleton
B0045471biological_processresponse to ethanol
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050544molecular_functionarachidonic acid binding
B0050729biological_processpositive regulation of inflammatory response
B0050786molecular_functionRAGE receptor binding
B0050832biological_processdefense response to fungus
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0051493biological_processregulation of cytoskeleton organization
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0070488biological_processneutrophil aggregation
B1990660cellular_componentcalprotectin complex
B2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 101
ChainResidue
AASP59
AASN61
AASP63
AALA65
AGLU70
AHOH140

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 102
ChainResidue
ASER20
ALYS23
AASN25
AALA28
ATYR30
AHOH141

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 101
ChainResidue
BASP59
BASN61
BASP63
BALA65
BGLU70
BHOH165

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 102
ChainResidue
BSER20
BLYS23
BASN25
BALA28
BHOH166

site_idEF1
Number of Residues4
DetailsCALCIUM BINDING SITE IN EF HAND
ChainResidue
ASER20
ALYS23
AASN25
AALA28

site_idEF2
Number of Residues4
DetailsCALCIUM BINDING SITE IN EF HAND
ChainResidue
AASP59
AASN61
AASP63
AALA65

site_idEF3
Number of Residues4
DetailsCALCIUM BINDING SITE IN EF HAND
ChainResidue
BLYS23
BASN25
BALA28
BSER20

site_idEF4
Number of Residues4
DetailsCALCIUM BINDING SITE IN EF HAND
ChainResidue
BASP59
BASN61
BASP63
BALA65

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DINTDGAVNfqEF
ChainResidueDetails
AASP59-PHE71

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. WFkeLDintDgavNFqEFliLV
ChainResidueDetails
ATRP54-VAL75

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AHIS17
BHIS87
AHIS27
AASP33
AHIS83
AHIS87
BHIS17
BHIS27
BASP33
BHIS83

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
AASP59
AASN61
AASP63
AGLU70
BASP59
BASN61
BASP63
BGLU70

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:18832721
ChainResidueDetails
ACYS42
BCYS42

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon