1MP6

Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015078	molecular_function	proton transmembrane transporter activity
A	0033644	cellular_component	host cell membrane
A	0055036	cellular_component	virion membrane
A	1902600	biological_process	proton transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069

Chain	Residue	Details
A	SER23-LEU43

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069

Chain	Residue	Details
A	HIS37

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069

Chain	Residue	Details
A	TRP41

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