1ML9

Structure of the Neurospora SET domain protein DIM-5, a histone lysine methyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003690	molecular_function	double-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006338	biological_process	chromatin remodeling
A	0008168	molecular_function	methyltransferase activity
A	0008270	molecular_function	zinc ion binding
A	0032259	biological_process	methylation
A	0042054	molecular_function	histone methyltransferase activity
A	0046872	molecular_function	metal ion binding
A	0046974	molecular_function	histone H3K9 methyltransferase activity
A	0140949	molecular_function	histone H3K9 trimethyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS66
A	CYS81
A	CYS128
A	CYS132

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	CYS74
A	CYS128
A	CYS134
A	CYS138

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3

Chain	Residue
A	CYS68
A	CYS74
A	CYS79
A	CYS66

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:12372305, ECO:0000269|PubMed:12887903, ECO:0007744|PDB:1ML9, ECO:0007744|PDB:1PEG

Chain	Residue	Details
A	CYS66
A	CYS68
A	CYS74
A	CYS79
A	CYS81
A	CYS128
A	CYS132
A	CYS134
A	CYS138

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site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:12887903, ECO:0007744|PDB:1PEG

Chain	Residue	Details
A	ARG159
A	ASP202
A	TYR204
A	ARG238
A	ASN241
A	CYS244
A	CYS306
A	CYS308
A	CYS313

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Interacts with H3S10 => ECO:0000269|PubMed:18215768

Chain	Residue	Details
A	THR196

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Interacts with H3R8 => ECO:0000269|PubMed:18215768

Chain	Residue	Details
A	PRO214

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 691

Chain	Residue	Details
A	TYR178	activator, electrostatic stabiliser, proton acceptor, proton donor
A	TYR283	electrostatic stabiliser

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