1ML9
Structure of the Neurospora SET domain protein DIM-5, a histone lysine methyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005694 | cellular_component | chromosome |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0140949 | molecular_function | histone H3K9 trimethyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | CYS66 |
| A | CYS81 |
| A | CYS128 |
| A | CYS132 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 2 |
| Chain | Residue |
| A | CYS74 |
| A | CYS128 |
| A | CYS134 |
| A | CYS138 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 3 |
| Chain | Residue |
| A | CYS68 |
| A | CYS74 |
| A | CYS79 |
| A | CYS66 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 135 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12372305","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12887903","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ML9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PEG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12887903","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PEG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interacts with H3S10","evidences":[{"source":"PubMed","id":"18215768","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interacts with H3R8","evidences":[{"source":"PubMed","id":"18215768","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 691 |
| Chain | Residue | Details |
| A | TYR178 | activator, electrostatic stabiliser, proton acceptor, proton donor |
| A | TYR283 | electrostatic stabiliser |
