1MJO

METHIONINE HOLOREPRESSOR MUTANT (Q44K) PLUS COREPRESSOR (S-ADENOSYL METHIONINE) COMPLEXED TO THE MINIMAL MET CONSENSUS OPERATOR WITH THE CENTRAL TA STEP MUTATED TO AT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006555	biological_process	methionine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006555	biological_process	methionine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009086	biological_process	methionine biosynthetic process
B	0045892	biological_process	negative regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006555	biological_process	methionine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009086	biological_process	methionine biosynthetic process
C	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006555	biological_process	methionine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009086	biological_process	methionine biosynthetic process
D	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 202

Chain	Residue
A	GLU90
A	GLU94
A	HOH272
B	GLU90
B	GLU94
B	HOH1344
D	HOH3367

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site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAM A 199

Chain	Residue
A	ARG43
A	LEU56
A	GLU59
A	ALA60
A	HIS63
A	PRO71
A	HOH212
A	HOH262
A	HOH299
A	HOH1304
A	HOH1353
A	HOH1395
B	PHE61
B	HIS63
B	ALA64
B	PHE65
B	GLY67
B	HOH1336
A	GLU39
A	ARG42

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site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAM B 200

Chain	Residue
A	PHE61
A	HIS63
A	ALA64
A	PHE65
A	GLY67
A	HOH233
A	HOH1353
B	GLU39
B	ARG43
B	LEU56
B	GLU59
B	ALA60
B	HIS63
B	PRO71
B	HOH218
B	HOH245
B	HOH1303
B	HOH1355

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site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAM C 200

Chain	Residue
C	PHE61
C	HIS63
C	ALA64
C	PHE65
C	GLY67
C	HOH2331
C	HOH2344
C	HOH3346
C	HOH3373
D	GLU39
D	ARG42
D	ARG43
D	LEU56
D	GLU59
D	ALA60
D	HIS63
D	PRO71

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site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAM D 200

Chain	Residue
C	GLU39
C	ARG42
C	ARG43
C	LEU56
C	GLU59
C	HIS63
C	PRO71
D	PHE61
D	HIS63
D	ALA64
D	PHE65
D	GLY67
D	HOH2324
D	HOH2348
D	HOH2366
D	HOH3337
D	HOH3366

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