Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1MJG

CRYSTAL STRUCTURE OF BIFUNCTIONAL CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE(CODH/ACS) FROM MOORELLA THERMOACETICA (F. CLOSTRIDIUM THERMOACETICUM)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004601	molecular_function	peroxidase activity
A	0006091	biological_process	generation of precursor metabolites and energy
A	0015977	biological_process	carbon fixation
A	0016151	molecular_function	nickel cation binding
A	0016491	molecular_function	oxidoreductase activity
A	0018492	molecular_function	obsolete carbon-monoxide dehydrogenase (acceptor) activity
A	0042542	biological_process	response to hydrogen peroxide
A	0043885	molecular_function	anaerobic carbon-monoxide dehydrogenase activity
A	0046872	molecular_function	metal ion binding
A	0050418	molecular_function	hydroxylamine reductase activity
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0098869	biological_process	cellular oxidant detoxification
B	0003824	molecular_function	catalytic activity
B	0004601	molecular_function	peroxidase activity
B	0006091	biological_process	generation of precursor metabolites and energy
B	0015977	biological_process	carbon fixation
B	0016151	molecular_function	nickel cation binding
B	0016491	molecular_function	oxidoreductase activity
B	0018492	molecular_function	obsolete carbon-monoxide dehydrogenase (acceptor) activity
B	0042542	biological_process	response to hydrogen peroxide
B	0043885	molecular_function	anaerobic carbon-monoxide dehydrogenase activity
B	0046872	molecular_function	metal ion binding
B	0050418	molecular_function	hydroxylamine reductase activity
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0098869	biological_process	cellular oxidant detoxification
C	0003824	molecular_function	catalytic activity
C	0004601	molecular_function	peroxidase activity
C	0006091	biological_process	generation of precursor metabolites and energy
C	0015977	biological_process	carbon fixation
C	0016151	molecular_function	nickel cation binding
C	0016491	molecular_function	oxidoreductase activity
C	0018492	molecular_function	obsolete carbon-monoxide dehydrogenase (acceptor) activity
C	0042542	biological_process	response to hydrogen peroxide
C	0043885	molecular_function	anaerobic carbon-monoxide dehydrogenase activity
C	0046872	molecular_function	metal ion binding
C	0050418	molecular_function	hydroxylamine reductase activity
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0098869	biological_process	cellular oxidant detoxification
D	0003824	molecular_function	catalytic activity
D	0004601	molecular_function	peroxidase activity
D	0006091	biological_process	generation of precursor metabolites and energy
D	0015977	biological_process	carbon fixation
D	0016151	molecular_function	nickel cation binding
D	0016491	molecular_function	oxidoreductase activity
D	0018492	molecular_function	obsolete carbon-monoxide dehydrogenase (acceptor) activity
D	0042542	biological_process	response to hydrogen peroxide
D	0043885	molecular_function	anaerobic carbon-monoxide dehydrogenase activity
D	0046872	molecular_function	metal ion binding
D	0050418	molecular_function	hydroxylamine reductase activity
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0098869	biological_process	cellular oxidant detoxification
M	0003824	molecular_function	catalytic activity
M	0006084	biological_process	acetyl-CoA metabolic process
M	0015977	biological_process	carbon fixation
M	0016491	molecular_function	oxidoreductase activity
M	0016740	molecular_function	transferase activity
M	0018492	molecular_function	obsolete carbon-monoxide dehydrogenase (acceptor) activity
M	0043884	molecular_function	CO-methylating acetyl-CoA synthase activity
M	0046872	molecular_function	metal ion binding
M	0051539	molecular_function	4 iron, 4 sulfur cluster binding
N	0003824	molecular_function	catalytic activity
N	0006084	biological_process	acetyl-CoA metabolic process
N	0015977	biological_process	carbon fixation
N	0016491	molecular_function	oxidoreductase activity
N	0016740	molecular_function	transferase activity
N	0018492	molecular_function	obsolete carbon-monoxide dehydrogenase (acceptor) activity
N	0043884	molecular_function	CO-methylating acetyl-CoA synthase activity
N	0046872	molecular_function	metal ion binding
N	0051539	molecular_function	4 iron, 4 sulfur cluster binding
O	0003824	molecular_function	catalytic activity
O	0006084	biological_process	acetyl-CoA metabolic process
O	0015977	biological_process	carbon fixation
O	0016491	molecular_function	oxidoreductase activity
O	0016740	molecular_function	transferase activity
O	0018492	molecular_function	obsolete carbon-monoxide dehydrogenase (acceptor) activity
O	0043884	molecular_function	CO-methylating acetyl-CoA synthase activity
O	0046872	molecular_function	metal ion binding
O	0051539	molecular_function	4 iron, 4 sulfur cluster binding
P	0003824	molecular_function	catalytic activity
P	0006084	biological_process	acetyl-CoA metabolic process
P	0015977	biological_process	carbon fixation
P	0016491	molecular_function	oxidoreductase activity
P	0016740	molecular_function	transferase activity
P	0018492	molecular_function	obsolete carbon-monoxide dehydrogenase (acceptor) activity
P	0043884	molecular_function	CO-methylating acetyl-CoA synthase activity
P	0046872	molecular_function	metal ion binding
P	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU1 M 901

Chain	Residue
M	CYS509
M	CYS595
M	CYS597
M	SF4900
M	NI902
M	ACT950

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI M 902

Chain	Residue
M	PHE598
M	CU1901
M	ACT950
M	CYS595
M	GLY596
M	CYS597

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT M 950

Chain	Residue
M	VAL149
M	PHE229
M	CYS509
M	CYS595
M	CYS597
M	CU1901
M	NI902

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU1 N 901

Chain	Residue
N	CYS509
N	CYS595
N	CYS597
N	SF4900
N	NI902
N	ACT950

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI N 902

Chain	Residue
N	CYS595
N	GLY596
N	CYS597
N	PHE598
N	CU1901
N	ACT950

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT N 950

Chain	Residue
N	GLY145
N	ILE146
N	PHE229
N	CYS509
N	CYS595
N	CYS597
N	CU1901
N	NI902

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU1 O 901

Chain	Residue
O	CYS509
O	CYS595
O	CYS597
O	SF4900
O	NI902
O	ACT950

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NI O 902

Chain	Residue
O	LEU527
O	CYS595
O	GLY596
O	CYS597
O	PHE598
O	CU1901
O	ACT950

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT O 950

Chain	Residue
O	GLY145
O	VAL149
O	PHE229
O	CYS509
O	CYS595
O	CYS597
O	CU1901
O	NI902

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU1 P 901

Chain	Residue
P	CYS509
P	CYS595
P	CYS597
P	SF4900
P	NI902
P	ACT950

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI P 902

Chain	Residue
P	CYS595
P	GLY596
P	CYS597
P	PHE598
P	CU1901
P	ACT950

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT P 950

Chain	Residue
P	GLY145
P	VAL149
P	CYS509
P	CYS595
P	CYS597
P	CU1901
P	NI902

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 A 700

Chain	Residue
A	CYS59
A	GLY62
A	CYS67
A	ARG69
B	CYS59
B	GLY62
B	CYS67
B	ARG69

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SF4 A 750

Chain	Residue
A	CYS68
A	CYS71
A	GLY74
A	CYS76
A	CYS90
A	ARG100
A	MET221

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE XCC A 800

Chain	Residue
A	CYS500
A	CYS550
A	SER585
A	LYS587
A	HIS283
A	CYS317
A	CYS355
A	GLY469
A	CYS470

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SF4 B 750

Chain	Residue
B	CYS68
B	CYS71
B	CYS76
B	CYS90
B	ARG100
B	MET221

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE XCC B 800

Chain	Residue
B	HIS283
B	CYS317
B	CYS355
B	GLY469
B	CYS470
B	CYS500
B	CYS550
B	SER585
B	LYS587

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 C 700

Chain	Residue
C	CYS59
C	GLY62
C	CYS67
C	ARG69
D	CYS59
D	GLY62
D	CYS67
D	ARG69

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SF4 C 750

Chain	Residue
C	CYS68
C	CYS71
C	CYS76
C	CYS90
C	ARG100
C	MET221

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE XCC C 800

Chain	Residue
C	HIS283
C	CYS317
C	CYS355
C	GLY469
C	CYS470
C	CYS500
C	CYS550
C	SER585
C	LYS587

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SF4 D 750

Chain	Residue
D	CYS68
D	CYS71
D	CYS76
D	CYS90
D	ARG100
D	MET221

site_id	CC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE XCC D 800

Chain	Residue
D	HIS283
D	CYS317
D	CYS355
D	GLY469
D	CYS470
D	CYS500
D	CYS550
D	SER585
D	LYS587

site_id	CC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 M 900

Chain	Residue
M	ILE146
M	CYS506
M	CYS509
M	CYS518
M	LEU527
M	CYS528
M	CYS597
M	CU1901

site_id	CC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 N 900

Chain	Residue
N	ILE146
N	CYS506
N	CYS509
N	CYS518
N	LEU527
N	CYS528
N	CYS595
N	CYS597
N	CU1901

site_id	CC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 O 900

Chain	Residue
O	CYS506
O	CYS509
O	CYS518
O	LEU527
O	CYS528
O	CYS595
O	CYS597
O	CU1901

site_id	CC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 P 900

Chain	Residue
P	CYS506
P	CYS509
P	CYS518
P	LEU527
P	CYS528
P	CYS595
P	CYS597
P	CU1901

Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	18
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. LGILVDIYGRKmqadfeG

Chain	Residue	Details
M	LEU384-GLY401

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	BINDING:

Chain	Residue	Details
M	CYS506
N	CYS518
N	CYS528
N	CYS595
N	GLY596
N	CYS597
O	CYS506
O	CYS509
O	CYS518
O	CYS528
O	CYS595
M	CYS509
O	GLY596
O	CYS597
P	CYS506
P	CYS509
P	CYS518
P	CYS528
P	CYS595
P	GLY596
P	CYS597
C	CYS76
M	CYS518
C	CYS90
C	HIS283
C	CYS317
C	CYS355
C	CYS470
C	CYS500
C	CYS550
D	CYS59
D	CYS67
D	CYS68
M	CYS528
D	CYS71
D	CYS76
D	CYS90
D	HIS283
D	CYS317
D	CYS355
D	CYS470
D	CYS500
D	CYS550
M	CYS595
M	GLY596
M	CYS597
N	CYS506
N	CYS509

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)