1MEJ

Human Glycinamide Ribonucleotide Transformylase domain at pH 8.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009058	biological_process	biosynthetic process
B	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
B	0006189	biological_process	'de novo' IMP biosynthetic process
B	0009058	biological_process	biosynthetic process
C	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
C	0006189	biological_process	'de novo' IMP biosynthetic process
C	0009058	biological_process	biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 B 450

Chain	Residue
B	GLY11
B	HOH522
B	SER12
B	ASN13
B	LYS170
B	HOH451
B	HOH456
B	HOH460
B	HOH505
B	HOH520

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 451

Chain	Residue
A	THR10
A	GLY11
A	SER12
A	ASN13
A	LYS170
A	HOH474
A	HOH492

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 452

Chain	Residue
C	THR10
C	GLY11
C	SER12
C	ASN13
C	HOH462

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Functional Information from PROSITE/UniProt

site_id	PS00373
Number of Residues	24
Details	GART Phosphoribosylglycinamide formyltransferase active site. GcTVhFVaEdVDaGqiIlqeavpV

Chain	Residue	Details
B	GLY133-VAL156

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P08179

Chain	Residue	Details
B	HIS108
A	HIS108
C	HIS108

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:12450384, ECO:0000269|PubMed:16026156, ECO:0007744|PDB:1MEN, ECO:0007744|PDB:1ZLY

Chain	Residue	Details
B	GLY11
B	LYS170
A	GLY11
A	LYS170
C	GLY11
C	LYS170

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0007744|PDB:1NJS

Chain	Residue	Details
B	ARG64
B	ASN106
A	ARG64
A	ASN106
C	ARG64
C	ASN106

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site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:16026156, ECO:0007744|PDB:1NJS, ECO:0007744|PDB:1ZLY

Chain	Residue	Details
B	MET89
B	ALA140
A	MET89
A	ALA140
C	MET89
C	ALA140

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site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Raises pKa of active site His => ECO:0000250|UniProtKB:P08179

Chain	Residue	Details
B	ASP144
A	ASP144
C	ASP144

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