1MEH
Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP and MOA bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003938 | molecular_function | IMP dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 900 |
| Chain | Residue |
| A | GLY20 |
| A | SER22 |
| A | ASP264 |
| A | PHE266 |
| A | ASN460 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE IMP A 602 |
| Chain | Residue |
| A | CSO319 |
| A | ASP358 |
| A | GLY359 |
| A | GLY360 |
| A | MET379 |
| A | LEU380 |
| A | GLY381 |
| A | ARG382 |
| A | TYR405 |
| A | GLY407 |
| A | GLU408 |
| A | GLY409 |
| A | GLU431 |
| A | MOA600 |
| A | HOH910 |
| A | HOH934 |
| A | HOH942 |
| A | HOH951 |
| A | HOH963 |
| A | HOH967 |
| A | ALA57 |
| A | GLY316 |
| A | SER317 |
| A | ILE318 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE MOA A 600 |
| Chain | Residue |
| A | ASP261 |
| A | SER262 |
| A | SER263 |
| A | ASN291 |
| A | GLY312 |
| A | ILE313 |
| A | GLY314 |
| A | GLU408 |
| A | GLY409 |
| A | ARG414 |
| A | GLU431 |
| A | IMP602 |
| A | HOH921 |
Functional Information from PROSITE/UniProt
| site_id | PS00487 |
| Number of Residues | 13 |
| Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. IKIGIGgGSICiT |
| Chain | Residue | Details |
| A | ILE309-THR321 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Thioimidate intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12235158","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12549902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"12549902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 13 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12549902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
