1MEG

CRYSTAL STRUCTURE OF A CARICAIN D158E MUTANT IN COMPLEX WITH E-64

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE E64 A 217

Chain	Residue
A	TYR67
A	VAL133
A	GLU158
A	HIS159
A	HOH310
A	GLN19
A	GLY23
A	SER24
A	CYS25
A	TRP26
A	GLY65
A	GLY66

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 218

Chain	Residue
A	HIS18
A	GLY20
A	ALA90
A	HOH312

---

site_id	ACT
Number of Residues	2
Details	ACTIVE SITE.

Chain	Residue
A	CYS25
A	HIS159

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Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGsCGSCWAfSA

Chain	Residue	Details
A	GLN19-ALA30

---

site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YILiKNSWgtaWGekGYIrI

Chain	Residue	Details
A	TYR174-ILE193

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000305|PubMed:8769310, ECO:0007744|PDB:1MEG

Chain	Residue	Details
A	CYS25

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089

Chain	Residue	Details
A	HIS159

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090

Chain	Residue	Details
A	ASN179

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: covalent => ECO:0000269|PubMed:8769310, ECO:0007744|PDB:1MEG

Chain	Residue	Details
A	CYS25

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	ASN179
A	CYS25
A	HIS159

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	GLN19
A	CYS25
A	HIS159

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	ASN179
A	GLN19
A	HIS159

---