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1MD4

A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to valine

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0002674biological_processnegative regulation of acute inflammatory response
A0004364molecular_functionglutathione transferase activity
A0004602molecular_functionglutathione peroxidase activity
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006469biological_processnegative regulation of protein kinase activity
A0006629biological_processlipid metabolic process
A0006693biological_processprostaglandin metabolic process
A0006749biological_processglutathione metabolic process
A0006805biological_processxenobiotic metabolic process
A0007417biological_processcentral nervous system development
A0008432molecular_functionJUN kinase binding
A0009890biological_processnegative regulation of biosynthetic process
A0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
A0016740molecular_functiontransferase activity
A0019207molecular_functionkinase regulator activity
A0031982cellular_componentvesicle
A0032691biological_processnegative regulation of interleukin-1 beta production
A0032720biological_processnegative regulation of tumor necrosis factor production
A0032872biological_processregulation of stress-activated MAPK cascade
A0032873biological_processnegative regulation of stress-activated MAPK cascade
A0032930biological_processpositive regulation of superoxide anion generation
A0034774cellular_componentsecretory granule lumen
A0035726biological_processcommon myeloid progenitor cell proliferation
A0035730molecular_functionS-nitrosoglutathione binding
A0035731molecular_functiondinitrosyl-iron complex binding
A0035732biological_processnitric oxide storage
A0043066biological_processnegative regulation of apoptotic process
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043407biological_processnegative regulation of MAP kinase activity
A0043409biological_processnegative regulation of MAPK cascade
A0043508biological_processnegative regulation of JUN kinase activity
A0043651biological_processlinoleic acid metabolic process
A0048147biological_processnegative regulation of fibroblast proliferation
A0051122biological_processhepoxilin biosynthetic process
A0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
A0070026molecular_functionnitric oxide binding
A0070062cellular_componentextracellular exosome
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0070664biological_processnegative regulation of leukocyte proliferation
A0071222biological_processcellular response to lipopolysaccharide
A0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
A0097057cellular_componentTRAF2-GSTP1 complex
A0098869biological_processcellular oxidant detoxification
A1901687biological_processglutathione derivative biosynthetic process
A1904813cellular_componentficolin-1-rich granule lumen
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0000302biological_processresponse to reactive oxygen species
B0002674biological_processnegative regulation of acute inflammatory response
B0004364molecular_functionglutathione transferase activity
B0004602molecular_functionglutathione peroxidase activity
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006469biological_processnegative regulation of protein kinase activity
B0006629biological_processlipid metabolic process
B0006693biological_processprostaglandin metabolic process
B0006749biological_processglutathione metabolic process
B0006805biological_processxenobiotic metabolic process
B0007417biological_processcentral nervous system development
B0008432molecular_functionJUN kinase binding
B0009890biological_processnegative regulation of biosynthetic process
B0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
B0016740molecular_functiontransferase activity
B0019207molecular_functionkinase regulator activity
B0031982cellular_componentvesicle
B0032691biological_processnegative regulation of interleukin-1 beta production
B0032720biological_processnegative regulation of tumor necrosis factor production
B0032872biological_processregulation of stress-activated MAPK cascade
B0032873biological_processnegative regulation of stress-activated MAPK cascade
B0032930biological_processpositive regulation of superoxide anion generation
B0034774cellular_componentsecretory granule lumen
B0035726biological_processcommon myeloid progenitor cell proliferation
B0035730molecular_functionS-nitrosoglutathione binding
B0035731molecular_functiondinitrosyl-iron complex binding
B0035732biological_processnitric oxide storage
B0043066biological_processnegative regulation of apoptotic process
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043407biological_processnegative regulation of MAP kinase activity
B0043409biological_processnegative regulation of MAPK cascade
B0043508biological_processnegative regulation of JUN kinase activity
B0043651biological_processlinoleic acid metabolic process
B0048147biological_processnegative regulation of fibroblast proliferation
B0051122biological_processhepoxilin biosynthetic process
B0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
B0070026molecular_functionnitric oxide binding
B0070062cellular_componentextracellular exosome
B0070372biological_processregulation of ERK1 and ERK2 cascade
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0070664biological_processnegative regulation of leukocyte proliferation
B0071222biological_processcellular response to lipopolysaccharide
B0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
B0097057cellular_componentTRAF2-GSTP1 complex
B0098869biological_processcellular oxidant detoxification
B1901687biological_processglutathione derivative biosynthetic process
B1904813cellular_componentficolin-1-rich granule lumen
B2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MES A 1001
ChainResidue
ATRP28
AGLU30
AGLU197
AHOH3068
BASP171

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MES B 2001
ChainResidue
BTRP28
BPHE192
BGLU197

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GSH A 3001
ChainResidue
APHE8
AARG13
ATRP38
ALYS44
AGLN51
ALEU52
APRO53
AGLN64
ASER65
AHOH3014
AHOH3060
AHOH3089
BASP98
ATYR7

site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE GSH B 4001
ChainResidue
AASP98
BTYR7
BPHE8
BARG13
BTRP38
BLYS44
BGLN51
BLEU52
BPRO53
BGLN64
BSER65
BHOH4021
BHOH4024
BHOH4054
BHOH4069

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518
ChainResidueDetails
APHE8
BALA45
BLEU52
BSER65
ACYS14
AGLN39
AALA45
ALEU52
ASER65
BPHE8
BCYS14
BGLN39

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by EGFR => ECO:0000269|PubMed:19254954
ChainResidueDetails
ATHR4
AVAL199
BTHR4
BVAL199

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ALEU62
BLEU62

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P19157
ChainResidueDetails
ATYR103
AASP116
BTYR103
BASP116

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
APRO128
BPRO128

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
ATYR7

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
BTYR7

226707

PDB entries from 2024-10-30

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