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1MAH

FASCICULIN2-MOUSE ACETYLCHOLINESTERASE COMPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0001919biological_processregulation of receptor recycling
A0002076biological_processosteoblast development
A0003990molecular_functionacetylcholinesterase activity
A0004104molecular_functioncholinesterase activity
A0005515molecular_functionprotein binding
A0005518molecular_functioncollagen binding
A0005576cellular_componentextracellular region
A0005604cellular_componentbasement membrane
A0005615cellular_componentextracellular space
A0005635cellular_componentnuclear envelope
A0005788cellular_componentendoplasmic reticulum lumen
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006581biological_processacetylcholine catabolic process
A0007155biological_processcell adhesion
A0007416biological_processsynapse assembly
A0008291biological_processacetylcholine metabolic process
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0017171molecular_functionserine hydrolase activity
A0019695biological_processcholine metabolic process
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031594cellular_componentneuromuscular junction
A0031623biological_processreceptor internalization
A0032868biological_processresponse to insulin
A0033265molecular_functioncholine binding
A0042166molecular_functionacetylcholine binding
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043083cellular_componentsynaptic cleft
A0043236molecular_functionlaminin binding
A0043621molecular_functionobsolete protein self-association
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0048471cellular_componentperinuclear region of cytoplasm
A0050772biological_processpositive regulation of axonogenesis
A0050775biological_processpositive regulation of dendrite morphogenesis
A0052689molecular_functioncarboxylic ester hydrolase activity
A0060041biological_processretina development in camera-type eye
A0095500biological_processacetylcholine receptor signaling pathway
A0098552cellular_componentside of membrane
A0120162biological_processpositive regulation of cold-induced thermogenesis
F0005576cellular_componentextracellular region
F0035821biological_processmodulation of process of another organism
F0090729molecular_functiontoxin activity
Functional Information from PDB Data
site_idCAT
Number of Residues4
DetailsLOCATED AT THE BOTTOM OF A NARROW GORGE
ChainResidue
ASER203
AGLU334
AHIS447
ATRP86

site_idPAS
Number of Residues4
DetailsBINDING SITE FOR FAS2 LOOP II
ChainResidue
ATYR72
ATYR124
AGLN279
ATYR341

Functional Information from PROSITE/UniProt
site_idPS00272
Number of Residues19
DetailsSNAKE_TOXIN Snake toxins signature. GCg..CPpgddnlevk.CCtsP
ChainResidueDetails
FGLY38-PRO56

site_idPS00122
Number of Residues16
DetailsCARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpmsVtLfGeSAG
ChainResidueDetails
APHE190-GLY205

site_idPS00941
Number of Residues11
DetailsCARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNVWtP
ChainResidueDetails
AGLU94-PRO104

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Blocks the entrance of the active site gorge of hAChE => ECO:0000303|PubMed:23679855
ChainResidueDetails
FMET33

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AGLU334
AHIS447

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN265

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AASN350
AASN464

Catalytic Information from CSA
site_idMCSA1
Number of Residues8
DetailsM-CSA 922
ChainResidueDetails
AGLY121electrostatic stabiliser
AGLY122electrostatic stabiliser
ASER203covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
AALA204electrostatic stabiliser
APHE295steric locator
AGLU334electrostatic stabiliser, modifies pKa
APHE338steric locator
AHIS447activator, hydrogen bond donor, proton acceptor, proton donor

218500

PDB entries from 2024-04-17

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