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1M9Y

X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000413biological_processprotein peptidyl-prolyl isomerization
A0001933biological_processnegative regulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0003723molecular_functionRNA binding
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006457biological_processprotein folding
A0006469biological_processnegative regulation of protein kinase activity
A0006915biological_processapoptotic process
A0016018molecular_functioncyclosporin A binding
A0016020cellular_componentmembrane
A0019076biological_processviral release from host cell
A0030168biological_processplatelet activation
A0030182biological_processneuron differentiation
A0030593biological_processneutrophil chemotaxis
A0030595biological_processleukocyte chemotaxis
A0031982cellular_componentvesicle
A0032148biological_processactivation of protein kinase B activity
A0032873biological_processnegative regulation of stress-activated MAPK cascade
A0032991cellular_componentprotein-containing complex
A0034389biological_processlipid droplet organization
A0034599biological_processcellular response to oxidative stress
A0034774cellular_componentsecretory granule lumen
A0035307biological_processpositive regulation of protein dephosphorylation
A0042118biological_processendothelial cell activation
A0043410biological_processpositive regulation of MAPK cascade
A0045069biological_processregulation of viral genome replication
A0045070biological_processpositive regulation of viral genome replication
A0046790molecular_functionvirion binding
A0050714biological_processpositive regulation of protein secretion
A0051082molecular_functionunfolded protein binding
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0060352biological_processcell adhesion molecule production
A0061944biological_processnegative regulation of protein K48-linked ubiquitination
A0070062cellular_componentextracellular exosome
A0070527biological_processplatelet aggregation
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1903901biological_processnegative regulation of viral life cycle
A1904399molecular_functionheparan sulfate binding
A1904813cellular_componentficolin-1-rich granule lumen
A2001233biological_processregulation of apoptotic signaling pathway
B0000413biological_processprotein peptidyl-prolyl isomerization
B0001933biological_processnegative regulation of protein phosphorylation
B0001934biological_processpositive regulation of protein phosphorylation
B0003723molecular_functionRNA binding
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0006457biological_processprotein folding
B0006469biological_processnegative regulation of protein kinase activity
B0006915biological_processapoptotic process
B0016018molecular_functioncyclosporin A binding
B0016020cellular_componentmembrane
B0019076biological_processviral release from host cell
B0030168biological_processplatelet activation
B0030182biological_processneuron differentiation
B0030593biological_processneutrophil chemotaxis
B0030595biological_processleukocyte chemotaxis
B0031982cellular_componentvesicle
B0032148biological_processactivation of protein kinase B activity
B0032873biological_processnegative regulation of stress-activated MAPK cascade
B0032991cellular_componentprotein-containing complex
B0034389biological_processlipid droplet organization
B0034599biological_processcellular response to oxidative stress
B0034774cellular_componentsecretory granule lumen
B0035307biological_processpositive regulation of protein dephosphorylation
B0042118biological_processendothelial cell activation
B0043410biological_processpositive regulation of MAPK cascade
B0045069biological_processregulation of viral genome replication
B0045070biological_processpositive regulation of viral genome replication
B0046790molecular_functionvirion binding
B0050714biological_processpositive regulation of protein secretion
B0051082molecular_functionunfolded protein binding
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0060352biological_processcell adhesion molecule production
B0061944biological_processnegative regulation of protein K48-linked ubiquitination
B0070062cellular_componentextracellular exosome
B0070527biological_processplatelet aggregation
B1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1903901biological_processnegative regulation of viral life cycle
B1904399molecular_functionheparan sulfate binding
B1904813cellular_componentficolin-1-rich granule lumen
B2001233biological_processregulation of apoptotic signaling pathway
C0016032biological_processviral process
D0016032biological_processviral process
E0000413biological_processprotein peptidyl-prolyl isomerization
E0001933biological_processnegative regulation of protein phosphorylation
E0001934biological_processpositive regulation of protein phosphorylation
E0003723molecular_functionRNA binding
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005178molecular_functionintegrin binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005925cellular_componentfocal adhesion
E0006457biological_processprotein folding
E0006469biological_processnegative regulation of protein kinase activity
E0006915biological_processapoptotic process
E0016018molecular_functioncyclosporin A binding
E0016020cellular_componentmembrane
E0019076biological_processviral release from host cell
E0030168biological_processplatelet activation
E0030182biological_processneuron differentiation
E0030593biological_processneutrophil chemotaxis
E0030595biological_processleukocyte chemotaxis
E0031982cellular_componentvesicle
E0032148biological_processactivation of protein kinase B activity
E0032873biological_processnegative regulation of stress-activated MAPK cascade
E0032991cellular_componentprotein-containing complex
E0034389biological_processlipid droplet organization
E0034599biological_processcellular response to oxidative stress
E0034774cellular_componentsecretory granule lumen
E0035307biological_processpositive regulation of protein dephosphorylation
E0042118biological_processendothelial cell activation
E0043410biological_processpositive regulation of MAPK cascade
E0045069biological_processregulation of viral genome replication
E0045070biological_processpositive regulation of viral genome replication
E0046790molecular_functionvirion binding
E0050714biological_processpositive regulation of protein secretion
E0051082molecular_functionunfolded protein binding
E0051092biological_processpositive regulation of NF-kappaB transcription factor activity
E0060352biological_processcell adhesion molecule production
E0061944biological_processnegative regulation of protein K48-linked ubiquitination
E0070062cellular_componentextracellular exosome
E0070527biological_processplatelet aggregation
E1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E1903901biological_processnegative regulation of viral life cycle
E1904399molecular_functionheparan sulfate binding
E1904813cellular_componentficolin-1-rich granule lumen
E2001233biological_processregulation of apoptotic signaling pathway
F0000413biological_processprotein peptidyl-prolyl isomerization
F0001933biological_processnegative regulation of protein phosphorylation
F0001934biological_processpositive regulation of protein phosphorylation
F0003723molecular_functionRNA binding
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0005178molecular_functionintegrin binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005925cellular_componentfocal adhesion
F0006457biological_processprotein folding
F0006469biological_processnegative regulation of protein kinase activity
F0006915biological_processapoptotic process
F0016018molecular_functioncyclosporin A binding
F0016020cellular_componentmembrane
F0019076biological_processviral release from host cell
F0030168biological_processplatelet activation
F0030182biological_processneuron differentiation
F0030593biological_processneutrophil chemotaxis
F0030595biological_processleukocyte chemotaxis
F0031982cellular_componentvesicle
F0032148biological_processactivation of protein kinase B activity
F0032873biological_processnegative regulation of stress-activated MAPK cascade
F0032991cellular_componentprotein-containing complex
F0034389biological_processlipid droplet organization
F0034599biological_processcellular response to oxidative stress
F0034774cellular_componentsecretory granule lumen
F0035307biological_processpositive regulation of protein dephosphorylation
F0042118biological_processendothelial cell activation
F0043410biological_processpositive regulation of MAPK cascade
F0045069biological_processregulation of viral genome replication
F0045070biological_processpositive regulation of viral genome replication
F0046790molecular_functionvirion binding
F0050714biological_processpositive regulation of protein secretion
F0051082molecular_functionunfolded protein binding
F0051092biological_processpositive regulation of NF-kappaB transcription factor activity
F0060352biological_processcell adhesion molecule production
F0061944biological_processnegative regulation of protein K48-linked ubiquitination
F0070062cellular_componentextracellular exosome
F0070527biological_processplatelet aggregation
F1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
F1903901biological_processnegative regulation of viral life cycle
F1904399molecular_functionheparan sulfate binding
F1904813cellular_componentficolin-1-rich granule lumen
F2001233biological_processregulation of apoptotic signaling pathway
G0016032biological_processviral process
H0016032biological_processviral process
Functional Information from PROSITE/UniProt
site_idPS00170
Number of Residues18
DetailsCSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG
ChainResidueDetails
ATYR48-GLY65

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
AMET1
BMET1
EMET1
FMET1

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N-acetylvaline; partial; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed => ECO:0000269|PubMed:25489052, ECO:0000269|Ref.12, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712
ChainResidueDetails
AVAL2
BVAL2
EVAL2
FVAL2

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS28
ALYS82
BLYS28
BLYS82
ELYS28
ELYS82
FLYS28
FLYS82

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS44
FLYS44
FLYS76
FLYS131
ALYS76
ALYS131
BLYS44
BLYS76
BLYS131
ELYS44
ELYS76
ELYS131

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER77
BSER77
ESER77
FSER77

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ATHR93
BTHR93
ETHR93
FTHR93

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:20364129, ECO:0000269|PubMed:25678563, ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS125
BLYS125
ELYS125
FLYS125

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P17742
ChainResidueDetails
ALYS133
BLYS133
ELYS133
FLYS133

site_idSWS_FT_FI9
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN108
BASN108
EASN108
FASN108

site_idSWS_FT_FI10
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
ALYS28
BLYS28
ELYS28
FLYS28

site_idSWS_FT_FI11
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS82
BLYS82
ELYS82
FLYS82

Catalytic Information from CSA
site_idMCSA1
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
AARG55electrostatic stabiliser, hydrogen bond donor, steric role
APHE60polar/non-polar interaction, steric role
AGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
AASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
APHE113polar/non-polar interaction, steric role
ALEU122polar/non-polar interaction, steric role
AHIS126polar/non-polar interaction, steric role

site_idMCSA2
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
BARG55electrostatic stabiliser, hydrogen bond donor, steric role
BPHE60polar/non-polar interaction, steric role
BGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
BASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
BPHE113polar/non-polar interaction, steric role
BLEU122polar/non-polar interaction, steric role
BHIS126polar/non-polar interaction, steric role

site_idMCSA3
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
EARG55electrostatic stabiliser, hydrogen bond donor, steric role
EPHE60polar/non-polar interaction, steric role
EGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
EASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
EPHE113polar/non-polar interaction, steric role
ELEU122polar/non-polar interaction, steric role
EHIS126polar/non-polar interaction, steric role

site_idMCSA4
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
FARG55electrostatic stabiliser, hydrogen bond donor, steric role
FPHE60polar/non-polar interaction, steric role
FGLN63electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
FASN102electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
FPHE113polar/non-polar interaction, steric role
FLEU122polar/non-polar interaction, steric role
FHIS126polar/non-polar interaction, steric role

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PDB entries from 2024-07-24

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