Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004517 | molecular_function | nitric-oxide synthase activity |
A | 0006809 | biological_process | nitric oxide biosynthetic process |
A | 0020037 | molecular_function | heme binding |
B | 0004517 | molecular_function | nitric-oxide synthase activity |
B | 0006809 | biological_process | nitric oxide biosynthetic process |
B | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 903 |
Chain | Residue |
A | CYS94 |
A | CYS99 |
B | CYS94 |
B | CYS99 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE HEM A 901 |
Chain | Residue |
A | TRP356 |
A | GLU361 |
A | TRP447 |
A | TYR475 |
A | 7NI906 |
A | HOH937 |
A | HOH1104 |
A | TRP178 |
A | ARG183 |
A | CYS184 |
A | PHE353 |
A | SER354 |
site_id | AC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE HEM B 901 |
Chain | Residue |
B | TRP178 |
B | ARG183 |
B | CYS184 |
B | PHE353 |
B | SER354 |
B | TRP356 |
B | MET358 |
B | GLU361 |
B | TRP447 |
B | PHE473 |
B | TYR475 |
B | 7NI907 |
B | HOH995 |
B | HOH1072 |
site_id | AC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE 7NI A 906 |
Chain | Residue |
A | PRO334 |
A | VAL336 |
A | GLY355 |
A | TRP356 |
A | TYR357 |
A | MET358 |
A | GLU361 |
A | HEM901 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE 7NI B 907 |
Chain | Residue |
B | PRO334 |
B | VAL336 |
B | GLY355 |
B | TRP356 |
B | TYR357 |
B | MET358 |
B | GLU361 |
B | HEM901 |
Functional Information from PROSITE/UniProt
site_id | PS60001 |
Number of Residues | 8 |
Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
Chain | Residue | Details |
A | ARG183-TRP190 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10074942, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:18849972, ECO:0000269|PubMed:25286850, ECO:0007744|PDB:1M9J, ECO:0007744|PDB:1M9K, ECO:0007744|PDB:1M9M, ECO:0007744|PDB:1M9Q, ECO:0007744|PDB:1M9R, ECO:0007744|PDB:3EAH, ECO:0007744|PDB:3NOS, ECO:0007744|PDB:4D1O, ECO:0007744|PDB:4D1P |
Chain | Residue | Details |
A | THR95 | |
A | LEU100 | |
B | THR95 | |
B | LEU100 | |
Chain | Residue | Details |
A | LEU103 | |
A | GLN476 | |
B | LEU103 | |
B | LEU248 | |
B | TYR357 | |
B | MET358 | |
B | ILE362 | |
B | LEU367 | |
B | TRP447 | |
B | ILE448 | |
B | HIS461 | |
A | LEU248 | |
B | GLN476 | |
A | TYR357 | |
A | MET358 | |
A | ILE362 | |
A | LEU367 | |
A | TRP447 | |
A | ILE448 | |
A | HIS461 | |
Chain | Residue | Details |
A | VAL185 | |
B | VAL185 | |
Chain | Residue | Details |
A | ASN366 | |
B | ASN366 | |
Chain | Residue | Details |
A | PRO115 | |
B | PRO115 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 3nos |
Chain | Residue | Details |
A | TRP356 | |
A | ARG187 | |
A | GLU361 | |
A | CYS184 | |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 3nos |
Chain | Residue | Details |
B | TRP356 | |
B | ARG187 | |
B | GLU361 | |
B | CYS184 | |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 935 |
Chain | Residue | Details |
A | VAL185 | metal ligand |
A | ILE188 | steric role |
A | TYR357 | electrostatic stabiliser |
A | ILE362 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 935 |
Chain | Residue | Details |
B | VAL185 | metal ligand |
B | ILE188 | steric role |
B | TYR357 | electrostatic stabiliser |
B | ILE362 | electrostatic stabiliser |