1M9I

Crystal Structure Of Phosphorylation-Mimicking Mutant T356D Of Annexin VI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001786	molecular_function	phosphatidylserine binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005544	molecular_function	calcium-dependent phospholipid binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005765	cellular_component	lysosomal membrane
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006816	biological_process	calcium ion transport
A	0008289	molecular_function	lipid binding
A	0012506	cellular_component	vesicle membrane
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0015485	molecular_function	cholesterol binding
A	0016020	cellular_component	membrane
A	0031012	cellular_component	extracellular matrix
A	0031902	cellular_component	late endosome membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042470	cellular_component	melanosome
A	0042802	molecular_function	identical protein binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051283	biological_process	negative regulation of sequestering of calcium ion
A	0051560	biological_process	mitochondrial calcium ion homeostasis
A	0070062	cellular_component	extracellular exosome
A	0097190	biological_process	apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 701

Chain	Residue
A	MET376
A	GLY378
A	LEU379
A	GLY380
A	GLU420

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 702

Chain	Residue
A	MET264
A	GLY266
A	GLY268
A	ASP308

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 703

Chain	Residue
A	MET612
A	GLY614
A	ALA615
A	GLY616
A	ASP656
A	HOH770

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 704

Chain	Residue
A	MET448
A	GLU449
A	GLY450
A	GLY452
A	ASP492

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 705

Chain	Residue
A	MET33
A	LYS34
A	GLY35
A	GLY37
A	GLU77

---

Functional Information from PROSITE/UniProt

site_id	PS00223
Number of Residues	53
Details	ANNEXIN_1 Annexin repeat signature. GSdkeaildiItsRsnrQrqEvcqsYkslygkdLiadLkyeltGkferlIvgL

Chain	Residue	Details
A	GLY37-LEU89
A	GLY109-LEU161
A	GLY193-VAL245
A	GLY268-LEU320
A	GLY380-LEU432
A	GLY452-LEU504
A	THR541-ILE593
A	GLY616-LEU668

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	71
Details	Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	71
Details	Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	71
Details	Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	71
Details	Repeat: {"description":"Annexin 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	71
Details	Repeat: {"description":"Annexin 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	74
Details	Repeat: {"description":"Annexin 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	71
Details	Repeat: {"description":"Annexin 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	9
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P14824","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P48037","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---