1M7H
Crystal Structure of APS kinase from Penicillium Chrysogenum: Structure with APS soaked out of one dimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000103 | biological_process | sulfate assimilation |
| A | 0004020 | molecular_function | adenylylsulfate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0070814 | biological_process | hydrogen sulfide biosynthetic process |
| B | 0000103 | biological_process | sulfate assimilation |
| B | 0004020 | molecular_function | adenylylsulfate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0070814 | biological_process | hydrogen sulfide biosynthetic process |
| C | 0000103 | biological_process | sulfate assimilation |
| C | 0004020 | molecular_function | adenylylsulfate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0009086 | biological_process | methionine biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016310 | biological_process | phosphorylation |
| C | 0019344 | biological_process | cysteine biosynthetic process |
| C | 0070814 | biological_process | hydrogen sulfide biosynthetic process |
| D | 0000103 | biological_process | sulfate assimilation |
| D | 0004020 | molecular_function | adenylylsulfate kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0009086 | biological_process | methionine biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016310 | biological_process | phosphorylation |
| D | 0019344 | biological_process | cysteine biosynthetic process |
| D | 0070814 | biological_process | hydrogen sulfide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1001 |
| Chain | Residue |
| C | ARG80 |
| C | PHE105 |
| C | ILE106 |
| C | HOH1328 |
| C | HOH1337 |
| C | HOH1342 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1002 |
| Chain | Residue |
| A | ILE106 |
| A | HOH1311 |
| A | HOH1312 |
| A | HOH1337 |
| A | HOH1367 |
| A | ARG66 |
| A | ARG80 |
| A | PHE105 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1003 |
| Chain | Residue |
| B | THR13 |
| B | ARG14 |
| B | SER15 |
| D | THR13 |
| D | ARG14 |
| D | SER15 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1004 |
| Chain | Residue |
| C | HIS8 |
| C | ALA9 |
| C | SER10 |
| C | HOH1379 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1005 |
| Chain | Residue |
| A | ARG110 |
| A | PRO175 |
| A | ALA176 |
| A | ASN177 |
| A | HOH1310 |
| A | HOH1376 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
| Chain | Residue |
| A | HIS8 |
| A | ALA9 |
| A | SER10 |
| B | HOH1359 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1007 |
| Chain | Residue |
| B | HIS8 |
| B | ALA9 |
| B | SER10 |
| C | ASP63 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1008 |
| Chain | Residue |
| C | ARG110 |
| C | PRO175 |
| C | ALA176 |
| C | ASN177 |
| C | HOH1310 |
| C | HOH1363 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1009 |
| Chain | Residue |
| A | TYR172 |
| A | GLU173 |
| A | ALA174 |
| A | HOH1398 |
| A | HOH1415 |
| D | LYS156 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1010 |
| Chain | Residue |
| A | ASP63 |
| D | PHE7 |
| D | HIS8 |
| D | ALA9 |
| D | SER10 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1011 |
| Chain | Residue |
| B | SER76 |
| C | SER76 |
| C | GLU77 |
| C | HOH1349 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1012 |
| Chain | Residue |
| A | GLU77 |
| A | HOH1386 |
| site_id | BC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP A 1301 |
| Chain | Residue |
| A | LEU33 |
| A | ALA35 |
| A | SER36 |
| A | GLY37 |
| A | LYS38 |
| A | SER39 |
| A | THR40 |
| A | ARG148 |
| A | PRO150 |
| A | ASN184 |
| A | LEU187 |
| A | VAL189 |
| A | HOH1316 |
| A | HOH1332 |
| A | HOH1333 |
| A | HOH1351 |
| A | HOH1369 |
| C | ARG148 |
| C | ADP1304 |
| C | HOH1311 |
| C | HOH1364 |
| site_id | BC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP B 1302 |
| Chain | Residue |
| B | HOH1390 |
| B | HOH1392 |
| B | HOH1395 |
| D | GLU186 |
| B | LEU33 |
| B | ALA35 |
| B | SER36 |
| B | GLY37 |
| B | LYS38 |
| B | SER39 |
| B | THR40 |
| B | ARG148 |
| B | PRO150 |
| B | LEU187 |
| B | HOH1317 |
| B | HOH1330 |
| B | HOH1341 |
| B | HOH1343 |
| B | HOH1350 |
| B | HOH1352 |
| B | HOH1382 |
| site_id | BC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADX B 1303 |
| Chain | Residue |
| B | SER34 |
| B | ARG66 |
| B | PHE75 |
| B | ARG80 |
| B | ASN83 |
| B | ILE84 |
| B | PHE105 |
| B | ILE106 |
| B | SER107 |
| B | PRO108 |
| B | LEU153 |
| B | LYS163 |
| B | GLU164 |
| B | THR166 |
| B | HOH1341 |
| B | HOH1387 |
| B | HOH1434 |
| site_id | BC7 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP C 1304 |
| Chain | Residue |
| A | ARG148 |
| A | ADP1301 |
| C | LEU33 |
| C | ALA35 |
| C | SER36 |
| C | GLY37 |
| C | LYS38 |
| C | SER39 |
| C | THR40 |
| C | ARG148 |
| C | ASN184 |
| C | LEU187 |
| C | HOH1311 |
| C | HOH1330 |
| C | HOH1338 |
| C | HOH1340 |
| C | HOH1343 |
| C | HOH1350 |
| C | HOH1364 |
| C | HOH1413 |
| site_id | BC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP D 1305 |
| Chain | Residue |
| B | GLU186 |
| D | LEU33 |
| D | ALA35 |
| D | SER36 |
| D | GLY37 |
| D | LYS38 |
| D | SER39 |
| D | THR40 |
| D | ARG148 |
| D | PRO150 |
| D | ASN184 |
| D | LEU187 |
| D | HOH1327 |
| D | HOH1335 |
| D | HOH1336 |
| D | HOH1337 |
| D | HOH1351 |
| D | HOH1353 |
| D | HOH1359 |
| D | HOH1381 |
| D | HOH1402 |
| site_id | BC9 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADX D 1306 |
| Chain | Residue |
| D | SER34 |
| D | ARG66 |
| D | PHE75 |
| D | ARG80 |
| D | ASN83 |
| D | ILE84 |
| D | PHE105 |
| D | ILE106 |
| D | SER107 |
| D | PRO108 |
| D | LEU153 |
| D | ILE162 |
| D | LYS163 |
| D | GLU164 |
| D | PHE165 |
| D | THR166 |
| D | HOH1337 |
| D | HOH1346 |
| D | HOH1358 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Phosphoserine intermediate => ECO:0000250 |
| Chain | Residue | Details |
| A | SER107 | |
| B | SER107 | |
| C | SER107 | |
| D | SER107 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY32 | |
| B | GLY32 | |
| C | GLY32 | |
| D | GLY32 |
