Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0043525 | biological_process | positive regulation of neuron apoptotic process |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0006915 | biological_process | apoptotic process |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0043525 | biological_process | positive regulation of neuron apoptotic process |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0006915 | biological_process | apoptotic process |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0043525 | biological_process | positive regulation of neuron apoptotic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 506 |
| Chain | Residue |
| A | ASP184 |
| A | THR216 |
| A | VAL217 |
| A | TYR220 |
| A | GLN279 |
| A | VAL280 |
| B | HIS207 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 503 |
| Chain | Residue |
| B | TYR53 |
| B | ASN54 |
| B | HIS57 |
| B | ASP127 |
| B | GLY168 |
| B | LYS169 |
| B | PRO170 |
| B | PRO45 |
| B | VAL46 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 507 |
| Chain | Residue |
| A | HIS207 |
| B | ASP184 |
| B | THR216 |
| B | VAL217 |
| B | GLN279 |
| B | VAL280 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 501 |
| Chain | Residue |
| C | GLU138 |
| C | GLY140 |
| C | MET141 |
| C | LEU142 |
| C | PRO151 |
| C | CYS178 |
| C | GLN179 |
| C | PHE214 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO C 502 |
| Chain | Residue |
| C | ASP248 |
| C | ILE249 |
| C | LEU250 |
| C | THR254 |
| C | LEU287 |
| C | ARG289 |
| C | LEU290 |
| C | LEU291 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 504 |
| Chain | Residue |
| C | ASP184 |
| C | HIS207 |
| C | THR216 |
| C | VAL217 |
| C | GLN279 |
| C | VAL280 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 508 |
| Chain | Residue |
| C | LEU183 |
| C | ASP184 |
| C | GLY185 |
| C | GLY186 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR CHAIN D OF ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE |
| Chain | Residue |
| A | LYS77 |
| A | ARG79 |
| A | THR135 |
| A | HIS136 |
| A | GLY137 |
| A | GLN176 |
| A | CYS178 |
| A | PHE221 |
| A | SER222 |
| A | TRP223 |
| A | ARG224 |
| A | ASN225 |
| A | THR226 |
| A | SER266 |
| A | ASN267 |
| A | MET274 |
| B | HIS74 |
| D | HOH1050 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR CHAIN E OF ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE |
| Chain | Residue |
| A | HIS74 |
| B | ARG79 |
| B | THR135 |
| B | HIS136 |
| B | GLY137 |
| B | GLN176 |
| B | CYS178 |
| B | PHE221 |
| B | SER222 |
| B | TRP223 |
| B | ARG224 |
| B | ASN225 |
| B | THR226 |
| B | SER266 |
| B | ASN267 |
| B | MET274 |
| E | HOH1013 |
| E | HOH1173 |
| site_id | BC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN F OF ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE |
| Chain | Residue |
| F | HOH1088 |
| F | HOH1091 |
| C | HIS74 |
| C | ARG79 |
| C | THR135 |
| C | HIS136 |
| C | GLY137 |
| C | GLN176 |
| C | CYS178 |
| C | PHE221 |
| C | SER222 |
| C | TRP223 |
| C | ARG224 |
| C | ASN225 |
| C | THR226 |
| C | SER266 |
| C | ASN267 |
Functional Information from PROSITE/UniProt
| site_id | PS01121 |
| Number of Residues | 15 |
| Details | CASPASE_HIS Caspase family histidine active site. HsdadCllVaVLTHG |
| Chain | Residue | Details |
| A | HIS123-GLY137 | |
| site_id | PS01122 |
| Number of Residues | 12 |
| Details | CASPASE_CYS Caspase family cysteine active site. KPKLFFIQACQG |
| Chain | Residue | Details |
| A | LYS169-GLY180 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS136 | |
| A | CYS178 | |
| B | HIS136 | |
| B | CYS178 | |
| C | HIS136 | |
| C | CYS178 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qx3 |
| Chain | Residue | Details |
| A | HIS136 | |
| A | GLY137 | |
| A | CYS178 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qx3 |
| Chain | Residue | Details |
| B | HIS136 | |
| B | GLY137 | |
| B | CYS178 | |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qx3 |
| Chain | Residue | Details |
| C | HIS136 | |
| C | GLY137 | |
| C | CYS178 | |
