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1M6W

Binary complex of Human glutathione-dependent formaldehyde dehydrogenase and 12-Hydroxydodecanoic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0001523biological_processretinoid metabolic process
A0003016biological_processrespiratory system process
A0004022molecular_functionalcohol dehydrogenase (NAD+) activity
A0005504molecular_functionfatty acid binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0008270molecular_functionzinc ion binding
A0009055molecular_functionelectron transfer activity
A0010430biological_processfatty acid omega-oxidation
A0016491molecular_functionoxidoreductase activity
A0018467molecular_functionformaldehyde dehydrogenase (NAD+) activity
A0032496biological_processresponse to lipopolysaccharide
A0042802molecular_functionidentical protein binding
A0044281biological_processsmall molecule metabolic process
A0045777biological_processpositive regulation of blood pressure
A0046294biological_processformaldehyde catabolic process
A0046872molecular_functionmetal ion binding
A0051409biological_processresponse to nitrosative stress
A0051775biological_processresponse to redox state
A0051903molecular_functionS-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
A0070062cellular_componentextracellular exosome
A0080007molecular_functionS-nitrosoglutathione reductase (NADH) activity
A0106321molecular_functionS-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity
A0106322molecular_functionS-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity
B0001523biological_processretinoid metabolic process
B0003016biological_processrespiratory system process
B0004022molecular_functionalcohol dehydrogenase (NAD+) activity
B0005504molecular_functionfatty acid binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0008270molecular_functionzinc ion binding
B0009055molecular_functionelectron transfer activity
B0010430biological_processfatty acid omega-oxidation
B0016491molecular_functionoxidoreductase activity
B0018467molecular_functionformaldehyde dehydrogenase (NAD+) activity
B0032496biological_processresponse to lipopolysaccharide
B0042802molecular_functionidentical protein binding
B0044281biological_processsmall molecule metabolic process
B0045777biological_processpositive regulation of blood pressure
B0046294biological_processformaldehyde catabolic process
B0046872molecular_functionmetal ion binding
B0051409biological_processresponse to nitrosative stress
B0051775biological_processresponse to redox state
B0051903molecular_functionS-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
B0070062cellular_componentextracellular exosome
B0080007molecular_functionS-nitrosoglutathione reductase (NADH) activity
B0106321molecular_functionS-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity
B0106322molecular_functionS-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1375
ChainResidue
ACYS96
ACYS99
ACYS102
ACYS110

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1376
ChainResidue
ACYS44
AHIS66
ACYS173
A12H4378

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1375
ChainResidue
BCYS99
BCYS102
BCYS110
BCYS96

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1376
ChainResidue
BCYS44
BHIS66
BCYS173
B12H5378

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 2001
ChainResidue
AALA186
ALYS187
AGLU189
ATYR263
AHOH4422
AHOH4479

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K B 2002
ChainResidue
BALA186
BLYS187
BGLU189
BTYR263
BHOH5520
BHOH5580
BHOH5660

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 A 3001
ChainResidue
ALYS314
AHOH4422
AHOH4560
BLYS314

site_idAC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 A 3002
ChainResidue
ALYS83
ALYS158
AHOH4470
AHOH4577
AHOH4592
AHOH4632
BLYS83

site_idAC9
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PO4 A 3003
ChainResidue
AHIS45
AGLY201
AVAL202
AARG368
AHOH4411
AHOH4570
AHOH4603
AHOH4628

site_idBC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 12H A 4378
ChainResidue
ACYS44
ATHR46
AHIS66
ATYR92
ALEU109
AGLN111
AARG114
AMET140
ACYS173
AGLY292
AALA317
AZN1376
AHOH4395
BLYS283

site_idBC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 12H B 5378
ChainResidue
ALYS283
BCYS44
BTHR46
BHIS66
BTYR92
BGLN111
BARG114
BCYS173
BVAL293
BALA317
BZN1376
BHOH5451

Functional Information from PROSITE/UniProt
site_idPS00059
Number of Residues15
DetailsADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEgAGIvesvGegV
ChainResidueDetails
AGLY65-VAL79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"3365377","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsSite: {"description":"Important for FDH activity and activation by fatty acids","evidences":[{"source":"PubMed","id":"8460164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8494891","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P28474","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1teh
ChainResidueDetails
ATHR46
AHIS45

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1teh
ChainResidueDetails
BTHR46
BHIS45

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1teh
ChainResidueDetails
AASP55

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1teh
ChainResidueDetails
BASP55

site_idMCSA1
Number of Residues12
DetailsM-CSA 464
ChainResidueDetails
ACYS44metal ligand
AARG114activator
ACYS173metal ligand
AARG368steric role
AHIS45proton shuttle (general acid/base)
ATHR46proton shuttle (general acid/base)
AHIS66metal ligand
AGLU67metal ligand
ACYS96metal ligand
ACYS99metal ligand
ACYS102metal ligand
ACYS110metal ligand

site_idMCSA2
Number of Residues12
DetailsM-CSA 464
ChainResidueDetails
BCYS44metal ligand
BARG114activator
BCYS173metal ligand
BARG368steric role
BHIS45proton shuttle (general acid/base)
BTHR46proton shuttle (general acid/base)
BHIS66metal ligand
BGLU67metal ligand
BCYS96metal ligand
BCYS99metal ligand
BCYS102metal ligand
BCYS110metal ligand

239149

PDB entries from 2025-07-23

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