1M4I
Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Kanamycin A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030649 | biological_process | aminoglycoside antibiotic catabolic process |
| A | 0034069 | molecular_function | aminoglycoside N-acetyltransferase activity |
| A | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0030649 | biological_process | aminoglycoside antibiotic catabolic process |
| B | 0034069 | molecular_function | aminoglycoside N-acetyltransferase activity |
| B | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE COA A 600 |
| Chain | Residue |
| A | ALA31 |
| A | LEU95 |
| A | VAL96 |
| A | TYR126 |
| A | HOH608 |
| A | HOH622 |
| A | HOH653 |
| A | HOH678 |
| A | HOH684 |
| A | HOH687 |
| A | HOH733 |
| A | PHE32 |
| A | HOH779 |
| A | HOH800 |
| A | HOH801 |
| A | HOH810 |
| A | HOH814 |
| B | ARG87 |
| B | ASP89 |
| B | HOH706 |
| A | VAL84 |
| A | ALA85 |
| A | VAL86 |
| A | ARG91 |
| A | GLY92 |
| A | GLN93 |
| A | ARG94 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE COA B 601 |
| Chain | Residue |
| B | ALA31 |
| B | PHE32 |
| B | VAL84 |
| B | ALA85 |
| B | VAL86 |
| B | ARG91 |
| B | GLY92 |
| B | GLN93 |
| B | ARG94 |
| B | LEU95 |
| B | VAL96 |
| B | HOH636 |
| B | HOH647 |
| B | HOH726 |
| B | HOH759 |
| B | HOH771 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE KAN A 500 |
| Chain | Residue |
| A | PHE32 |
| A | ASP35 |
| A | PHE36 |
| A | ASP40 |
| A | GLU82 |
| A | GLY83 |
| A | SER117 |
| A | ASP151 |
| A | ASP152 |
| A | TRP181 |
| A | HOH612 |
| A | HOH626 |
| A | HOH633 |
| A | HOH662 |
| A | HOH716 |
| A | HOH723 |
| A | HOH768 |
| A | HOH779 |
| A | HOH783 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE KAN B 501 |
| Chain | Residue |
| B | ASP35 |
| B | PHE36 |
| B | ASP40 |
| B | GLU82 |
| B | GLY83 |
| B | SER117 |
| B | SER119 |
| B | ALA120 |
| B | ASP151 |
| B | ASP152 |
| B | THR155 |
| B | TRP181 |
| B | HOH610 |
| B | HOH626 |
| B | HOH628 |
| B | HOH635 |
| B | HOH687 |
| B | HOH692 |
| B | HOH701 |
| B | HOH711 |
| B | HOH730 |
| B | HOH752 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PAP A 602 |
| Chain | Residue |
| B | ARG123 |
| B | ARG124 |
| B | HOH679 |
| B | HOH728 |
| A | HIS54 |
| A | HIS55 |
| A | ARG72 |
| A | ASP89 |
| A | TRP90 |
| A | GLN93 |
| A | HOH650 |
| A | HOH668 |
| A | HOH675 |
| A | HOH719 |
| A | HOH740 |
| A | HOH759 |
| A | HOH767 |
| A | HOH807 |
| B | GLY34 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 302 |
| Details | Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12161746","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12161746","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M4I","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
