1M4G
Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Ribostamycin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030649 | biological_process | aminoglycoside antibiotic catabolic process |
| A | 0034069 | molecular_function | aminoglycoside N-acetyltransferase activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0030649 | biological_process | aminoglycoside antibiotic catabolic process |
| B | 0034069 | molecular_function | aminoglycoside N-acetyltransferase activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE COA A 502 |
| Chain | Residue |
| A | ALA31 |
| A | LEU95 |
| A | VAL96 |
| A | SER119 |
| A | ARG121 |
| A | ARG124 |
| A | TYR126 |
| A | RIO500 |
| A | HOH516 |
| A | HOH549 |
| A | HOH551 |
| A | PHE32 |
| A | HOH565 |
| A | HOH595 |
| A | HOH598 |
| A | HOH643 |
| B | ARG87 |
| B | ASP89 |
| B | HOH725 |
| A | VAL84 |
| A | ALA85 |
| A | VAL86 |
| A | ARG91 |
| A | GLY92 |
| A | GLN93 |
| A | ARG94 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE COA B 503 |
| Chain | Residue |
| B | ALA31 |
| B | PHE32 |
| B | VAL84 |
| B | ALA85 |
| B | VAL86 |
| B | ARG91 |
| B | GLY92 |
| B | GLN93 |
| B | ARG94 |
| B | LEU95 |
| B | VAL96 |
| B | SER119 |
| B | ARG121 |
| B | TYR126 |
| B | RIO501 |
| B | HOH628 |
| B | HOH639 |
| B | HOH668 |
| B | HOH710 |
| B | HOH731 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE RIO A 500 |
| Chain | Residue |
| A | PHE32 |
| A | ASP35 |
| A | PHE36 |
| A | ASP40 |
| A | GLU82 |
| A | GLY83 |
| A | SER117 |
| A | SER119 |
| A | ASP152 |
| A | TRP181 |
| A | COA502 |
| A | HOH507 |
| A | HOH508 |
| A | HOH514 |
| A | HOH518 |
| A | HOH537 |
| A | HOH569 |
| A | HOH573 |
| A | HOH629 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE RIO B 501 |
| Chain | Residue |
| B | PHE32 |
| B | ASP35 |
| B | PHE36 |
| B | ASP40 |
| B | GLU82 |
| B | GLY83 |
| B | SER117 |
| B | SER119 |
| B | ASP152 |
| B | TRP181 |
| B | COA503 |
| B | PAP600 |
| B | HOH602 |
| B | HOH608 |
| B | HOH612 |
| B | HOH616 |
| B | HOH634 |
| B | HOH660 |
| B | HOH668 |
| B | HOH671 |
| B | HOH674 |
| B | HOH705 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PAP B 600 |
| Chain | Residue |
| B | HOH673 |
| B | HOH708 |
| B | HOH721 |
| B | HOH729 |
| B | HOH749 |
| A | HOH547 |
| B | GLU38 |
| B | THR39 |
| B | GLU42 |
| B | SER119 |
| B | ALA120 |
| B | ARG121 |
| B | ARG123 |
| B | ALA177 |
| B | RIO501 |
| B | PAP601 |
| B | HOH671 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PAP B 601 |
| Chain | Residue |
| A | ASN74 |
| A | GLN112 |
| A | ILE163 |
| A | SER164 |
| A | HOH572 |
| A | HOH602 |
| B | ARG124 |
| B | PAP600 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 302 |
| Details | Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12161746","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12161746","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M4I","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
