1M44
Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-APO Structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030649 | biological_process | aminoglycoside antibiotic catabolic process |
| A | 0034069 | molecular_function | aminoglycoside N-acetyltransferase activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0030649 | biological_process | aminoglycoside antibiotic catabolic process |
| B | 0034069 | molecular_function | aminoglycoside N-acetyltransferase activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 500 |
| Chain | Residue |
| A | THR37 |
| A | GLY178 |
| A | HOH521 |
| A | HOH554 |
| A | HOH633 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | LEU95 |
| A | VAL96 |
| A | HOH558 |
| A | HOH620 |
| A | ARG91 |
| A | GLY92 |
| A | GLN93 |
| A | ARG94 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 502 |
| Chain | Residue |
| B | THR37 |
| B | THR39 |
| B | GLY178 |
| B | HOH516 |
| B | HOH540 |
| B | HOH630 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 503 |
| Chain | Residue |
| B | ARG91 |
| B | GLY92 |
| B | GLN93 |
| B | ARG94 |
| B | LEU95 |
| B | VAL96 |
| B | HOH530 |
| B | HOH585 |
| B | HOH631 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 504 |
| Chain | Residue |
| A | ARG21 |
| A | ARG25 |
| A | TRP41 |
| A | HOH699 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 302 |
| Details | Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12161746","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12161746","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M4I","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
