1M35
Aminopeptidase P from Escherichia coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008235 | molecular_function | metalloexopeptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008235 | molecular_function | metalloexopeptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008235 | molecular_function | metalloexopeptidase activity |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0046914 | molecular_function | transition metal ion binding |
| C | 0051289 | biological_process | protein homotetramerization |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008235 | molecular_function | metalloexopeptidase activity |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0046914 | molecular_function | transition metal ion binding |
| D | 0051289 | biological_process | protein homotetramerization |
| D | 0070006 | molecular_function | metalloaminopeptidase activity |
| E | 0004177 | molecular_function | aminopeptidase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006508 | biological_process | proteolysis |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0008235 | molecular_function | metalloexopeptidase activity |
| E | 0008237 | molecular_function | metallopeptidase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0032991 | cellular_component | protein-containing complex |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0046914 | molecular_function | transition metal ion binding |
| E | 0051289 | biological_process | protein homotetramerization |
| E | 0070006 | molecular_function | metalloaminopeptidase activity |
| F | 0004177 | molecular_function | aminopeptidase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006508 | biological_process | proteolysis |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0008235 | molecular_function | metalloexopeptidase activity |
| F | 0008237 | molecular_function | metallopeptidase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0032991 | cellular_component | protein-containing complex |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0046914 | molecular_function | transition metal ion binding |
| F | 0051289 | biological_process | protein homotetramerization |
| F | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN A 2001 |
| Chain | Residue |
| A | ASP260 |
| A | ASP271 |
| A | THR273 |
| A | GLU406 |
| A | MN2002 |
| A | HOH2042 |
| A | HOH2150 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 2002 |
| Chain | Residue |
| A | GLU383 |
| A | GLU406 |
| A | MN2001 |
| A | HOH2150 |
| A | ASP271 |
| A | HIS354 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN B 2003 |
| Chain | Residue |
| B | ASP260 |
| B | ASP271 |
| B | THR273 |
| B | GLU406 |
| B | MN2004 |
| B | HOH2202 |
| B | HOH2203 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 2004 |
| Chain | Residue |
| B | ASP271 |
| B | HIS354 |
| B | GLU383 |
| B | GLU406 |
| B | MN2003 |
| B | HOH2202 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MN C 2005 |
| Chain | Residue |
| C | TYR229 |
| C | ASP260 |
| C | ASP271 |
| C | THR273 |
| C | GLU406 |
| C | MN2006 |
| C | HOH2049 |
| C | HOH2171 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 2006 |
| Chain | Residue |
| C | ASP271 |
| C | HIS354 |
| C | GLU383 |
| C | GLU406 |
| C | MN2005 |
| C | HOH2171 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN D 2007 |
| Chain | Residue |
| D | ASP260 |
| D | ASP271 |
| D | THR273 |
| D | GLU406 |
| D | MN2008 |
| D | HOH2067 |
| D | HOH2226 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN D 2008 |
| Chain | Residue |
| D | ASP271 |
| D | HIS354 |
| D | GLU383 |
| D | GLU406 |
| D | MN2007 |
| D | HOH2226 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MN E 2009 |
| Chain | Residue |
| E | TYR229 |
| E | ASP260 |
| E | ASP271 |
| E | THR273 |
| E | GLU406 |
| E | HOH614 |
| E | HOH1309 |
| E | MN2010 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN E 2010 |
| Chain | Residue |
| E | ASP271 |
| E | HIS354 |
| E | GLU383 |
| E | GLU406 |
| E | HOH1309 |
| E | HOH1610 |
| E | MN2009 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MN F 2011 |
| Chain | Residue |
| F | TYR229 |
| F | ASP260 |
| F | ASP271 |
| F | THR273 |
| F | GLU406 |
| F | HOH766 |
| F | HOH855 |
| F | MN2012 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN F 2012 |
| Chain | Residue |
| F | ASP271 |
| F | HIS354 |
| F | GLU383 |
| F | GLU406 |
| F | HOH855 |
| F | MN2011 |
Functional Information from PROSITE/UniProt
| site_id | PS00491 |
| Number of Residues | 13 |
| Details | PROLINE_PEPTIDASE Aminopeptidase P and proline dipeptidase signature. HGLSHwLGLdVHD |
| Chain | Residue | Details |
| A | HIS350-ASP362 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ALA261 | |
| B | ASP407 | |
| C | ALA261 | |
| C | ILE272 | |
| C | TRP355 | |
| C | PRO384 | |
| C | ASP407 | |
| D | ALA261 | |
| D | ILE272 | |
| D | TRP355 | |
| D | PRO384 | |
| A | ILE272 | |
| D | ASP407 | |
| E | ALA261 | |
| E | ILE272 | |
| E | TRP355 | |
| E | PRO384 | |
| E | ASP407 | |
| F | ALA261 | |
| F | ILE272 | |
| F | TRP355 | |
| F | PRO384 | |
| A | TRP355 | |
| F | ASP407 | |
| A | PRO384 | |
| A | ASP407 | |
| B | ALA261 | |
| B | ILE272 | |
| B | TRP355 | |
| B | PRO384 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 11 |
| Details | M-CSA 379 |
| Chain | Residue | Details |
| A | SER39 | activator, electrostatic stabiliser |
| A | ILE405 | proton shuttle (general acid/base) |
| A | ASP407 | metal ligand |
| A | TYR244 | electrostatic stabiliser |
| A | ALA261 | metal ligand, proton shuttle (general acid/base) |
| A | ILE272 | metal ligand |
| A | GLY351 | electrostatic stabiliser |
| A | TRP355 | metal ligand |
| A | ASP362 | electrostatic stabiliser |
| A | PRO384 | activator, metal ligand, proton shuttle (general acid/base) |
| A | ILE388 | proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 11 |
| Details | M-CSA 379 |
| Chain | Residue | Details |
| B | SER39 | activator, electrostatic stabiliser |
| B | ILE405 | proton shuttle (general acid/base) |
| B | ASP407 | metal ligand |
| B | TYR244 | electrostatic stabiliser |
| B | ALA261 | metal ligand, proton shuttle (general acid/base) |
| B | ILE272 | metal ligand |
| B | GLY351 | electrostatic stabiliser |
| B | TRP355 | metal ligand |
| B | ASP362 | electrostatic stabiliser |
| B | PRO384 | activator, metal ligand, proton shuttle (general acid/base) |
| B | ILE388 | proton shuttle (general acid/base) |
| site_id | MCSA3 |
| Number of Residues | 11 |
| Details | M-CSA 379 |
| Chain | Residue | Details |
| C | SER39 | activator, electrostatic stabiliser |
| C | ILE405 | proton shuttle (general acid/base) |
| C | ASP407 | metal ligand |
| C | TYR244 | electrostatic stabiliser |
| C | ALA261 | metal ligand, proton shuttle (general acid/base) |
| C | ILE272 | metal ligand |
| C | GLY351 | electrostatic stabiliser |
| C | TRP355 | metal ligand |
| C | ASP362 | electrostatic stabiliser |
| C | PRO384 | activator, metal ligand, proton shuttle (general acid/base) |
| C | ILE388 | proton shuttle (general acid/base) |
| site_id | MCSA4 |
| Number of Residues | 11 |
| Details | M-CSA 379 |
| Chain | Residue | Details |
| D | SER39 | activator, electrostatic stabiliser |
| D | ILE405 | proton shuttle (general acid/base) |
| D | ASP407 | metal ligand |
| D | TYR244 | electrostatic stabiliser |
| D | ALA261 | metal ligand, proton shuttle (general acid/base) |
| D | ILE272 | metal ligand |
| D | GLY351 | electrostatic stabiliser |
| D | TRP355 | metal ligand |
| D | ASP362 | electrostatic stabiliser |
| D | PRO384 | activator, metal ligand, proton shuttle (general acid/base) |
| D | ILE388 | proton shuttle (general acid/base) |
| site_id | MCSA5 |
| Number of Residues | 11 |
| Details | M-CSA 379 |
| Chain | Residue | Details |
| E | SER39 | activator, electrostatic stabiliser |
| E | ILE405 | proton shuttle (general acid/base) |
| E | ASP407 | metal ligand |
| E | TYR244 | electrostatic stabiliser |
| E | ALA261 | metal ligand, proton shuttle (general acid/base) |
| E | ILE272 | metal ligand |
| E | GLY351 | electrostatic stabiliser |
| E | TRP355 | metal ligand |
| E | ASP362 | electrostatic stabiliser |
| E | PRO384 | activator, metal ligand, proton shuttle (general acid/base) |
| E | ILE388 | proton shuttle (general acid/base) |
| site_id | MCSA6 |
| Number of Residues | 11 |
| Details | M-CSA 379 |
| Chain | Residue | Details |
| F | SER39 | activator, electrostatic stabiliser |
| F | ILE405 | proton shuttle (general acid/base) |
| F | ASP407 | metal ligand |
| F | TYR244 | electrostatic stabiliser |
| F | ALA261 | metal ligand, proton shuttle (general acid/base) |
| F | ILE272 | metal ligand |
| F | GLY351 | electrostatic stabiliser |
| F | TRP355 | metal ligand |
| F | ASP362 | electrostatic stabiliser |
| F | PRO384 | activator, metal ligand, proton shuttle (general acid/base) |
| F | ILE388 | proton shuttle (general acid/base) |
