1M2W
Pseudomonas fluorescens mannitol 2-dehydrogenase ternary complex with NAD and D-mannitol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019594 | biological_process | mannitol metabolic process |
| A | 0050086 | molecular_function | mannitol 2-dehydrogenase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019594 | biological_process | mannitol metabolic process |
| B | 0050086 | molecular_function | mannitol 2-dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAD A 5500 |
| Chain | Residue |
| A | GLY33 |
| A | THR132 |
| A | GLU133 |
| A | ASP190 |
| A | ASN191 |
| A | ARG231 |
| A | ILE232 |
| A | THR233 |
| A | ARG373 |
| A | MTL5600 |
| A | HOH5607 |
| A | VAL34 |
| A | HOH5677 |
| A | HOH5689 |
| A | HOH5690 |
| A | HOH5832 |
| A | HOH5858 |
| A | GLY35 |
| A | GLY36 |
| A | PHE37 |
| A | ARG66 |
| A | ASP69 |
| A | THR130 |
| A | ILE131 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAD B 6500 |
| Chain | Residue |
| B | GLY33 |
| B | VAL34 |
| B | GLY35 |
| B | GLY36 |
| B | PHE37 |
| B | ARG66 |
| B | ASP69 |
| B | THR130 |
| B | ILE131 |
| B | THR132 |
| B | GLU133 |
| B | ASP190 |
| B | ASN191 |
| B | ARG231 |
| B | ILE232 |
| B | THR233 |
| B | ARG373 |
| B | MTL6600 |
| B | HOH6604 |
| B | HOH6614 |
| B | HOH6682 |
| B | HOH6853 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MTL A 5600 |
| Chain | Residue |
| A | ASN191 |
| A | ASP230 |
| A | ARG231 |
| A | LYS295 |
| A | ASN300 |
| A | HIS303 |
| A | ARG373 |
| A | VAL374 |
| A | LYS381 |
| A | NAD5500 |
| A | HOH5677 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MTL B 6600 |
| Chain | Residue |
| B | ASN191 |
| B | ASP230 |
| B | ARG231 |
| B | LYS295 |
| B | ASN300 |
| B | HIS303 |
| B | ARG373 |
| B | VAL374 |
| B | LYS381 |
| B | NAD6500 |
| B | HOH6614 |
Functional Information from PROSITE/UniProt
| site_id | PS00974 |
| Number of Residues | 13 |
| Details | MANNITOL_DHGENASE Mannitol dehydrogenases signature. VsFpnAmVDRItP |
| Chain | Residue | Details |
| A | VAL222-PRO234 |
