1M2S

Solution Structure of A New Potassium Channels Blocker from the Venom of Chinese Scorpion Buthus martensi Karsch

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008200	molecular_function	ion channel inhibitor activity
A	0015459	molecular_function	potassium channel regulator activity
A	0017080	molecular_function	sodium channel regulator activity
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
A	0099106	molecular_function	ion channel regulator activity

Functional Information from PROSITE/UniProt

site_id	PS01138
Number of Residues	23
Details	SCORP_SHORT_TOXIN Scorpion short toxins signature. CwtaCkkvtgsgq.GKCQnnqCrC

Chain	Residue	Details
A	CYS14-CYS36

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Peptide: {"description":"Potassium channel toxin alpha-KTx 16.2","featureId":"PRO_0000035321"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	35
Details	Peptide: {"description":"Martentoxin-1","featureId":"PRO_0000035322"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	34
Details	Peptide: {"description":"Martentoxin-b","featureId":"PRO_0000431603"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for the inhibitory effect on KCNMA1 channels"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Basic residue of the functional dyad","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Aromatic residue of the functional dyad","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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