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1LXL

NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE

Functional Information from GO Data
ChainGOidnamespacecontents
A0001836biological_processrelease of cytochrome c from mitochondria
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005783cellular_componentendoplasmic reticulum
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0006897biological_processendocytosis
A0006915biological_processapoptotic process
A0006950biological_processresponse to stress
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0008637biological_processapoptotic mitochondrial changes
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030672cellular_componentsynaptic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0031966cellular_componentmitochondrial membrane
A0032465biological_processregulation of cytokinesis
A0034097biological_processresponse to cytokine
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0046902biological_processregulation of mitochondrial membrane permeability
A0051434molecular_functionBH3 domain binding
A0051607biological_processdefense response to virus
A0051707biological_processresponse to other organism
A0051881biological_processregulation of mitochondrial membrane potential
A0055085biological_processtransmembrane transport
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0097136cellular_componentBcl-2 family protein complex
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A1900118biological_processnegative regulation of execution phase of apoptosis
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1902531biological_processregulation of intracellular signal transduction
A1903077biological_processnegative regulation of protein localization to plasma membrane
A2001233biological_processregulation of apoptotic signaling pathway
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
A2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
ChainResidueDetails
ALEU130-GLY148

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
ChainResidueDetails
ATRP181-VAL192

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
ChainResidueDetails
AVAL86-ARG100

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
ChainResidueDetails
ASER4-TRP24

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues43
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues20
DetailsMotif: {"description":"BH4"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues14
DetailsMotif: {"description":"BH3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues19
DetailsMotif: {"description":"BH1"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues15
DetailsMotif: {"description":"BH2"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsSite: {"description":"Cleavage; by caspase-1"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PLK3","evidences":[{"source":"PubMed","id":"21840391","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"PubMed","id":"19917720","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

245396

PDB entries from 2025-11-26

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